Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 5/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.60 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.60 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.60 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.60 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | L3MBTL3 | Q96JM7 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL698353 | 0.92 | MGLL (0.59) | MGLLMEN1KMT2ACHRNB2CHRNB4 | |
| SCHEMBL15949370 | 0.91 | MGLL (0.61) | MGLLMEN1KMT2AHTTKDM4E | |
| SCHEMBL697763 | 0.90 | MGLL (0.58) | MGLLMEN1KMT2ACHRNB2CHRNB4 | |
| SCHEMBL912749 | 0.90 | MGLL (0.57) | MGLLMEN1KMT2ACHRNB2CHRNB4 | |
| SCHEMBL694196 | 0.88 | MGLL (0.55) | MGLLMEN1KMT2ACHRNB2CHRNB4 | |
| SCHEMBL693170 | 0.87 | MGLL (0.57) | MGLLMEN1KMT2ACHRNB2CHRNB4 | |
| SCHEMBL15949438 | 0.86 | TSHR (0.60) | MGLLMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL693780 | 0.86 | KMT2A (0.56) | MGLLMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL912159 | 0.86 | HRH3 (0.57) | MGLLMEN1KMT2AHTTSLC6A7 | |
| SCHEMBL15949278 | 0.85 | MGLL (0.57) | MGLLMEN1KMT2ACHRNB2CHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421823-B1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-01-14 | — | — | EP | disclosed |
| EP-2421825-B9 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-08-20 | — | — | EP | disclosed |
| EP-2421825-B1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-01-01 | — | — | EP | disclosed |