Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 4/20 | 0.64 |
| ▸ | ACACB | O00763 | 3/20 | 0.32 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.32 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.32 |
| ▸ | KDM5A | P29375 | 1/20 | 0.31 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1390002 | 0.90 | GPBAR1 (0.76) | GPBAR1ACACBKEAP1NFE2L2KDM5A | |
| SCHEMBL1390399 | 0.90 | GPBAR1 (0.76) | GPBAR1ACACBKEAP1NFE2L2KDM5A | |
| SCHEMBL1390400 | 0.90 | GPBAR1 (0.76) | GPBAR1ACACBKEAP1NFE2L2KDM5A | |
| SCHEMBL1390006 | 0.90 | GPBAR1 (0.76) | GPBAR1ACACBKEAP1NFE2L2KDM5A | |
| SCHEMBL1390005 | 0.90 | GPBAR1 (0.76) | GPBAR1ACACBKEAP1NFE2L2KDM5A | |
| SCHEMBL15949197 | 0.88 | GPBAR1 (0.65) | GPBAR1ACACBKDM5AKDM4C | |
| SCHEMBL15949262 | 0.88 | GPBAR1 (0.65) | GPBAR1ACACBKDM5AKDM4C | |
| SCHEMBL1390449 | 0.88 | GPBAR1 (0.64) | GPBAR1ACACBKEAP1NFE2L2KDM5A | |
| SCHEMBL1390448 | 0.88 | GPBAR1 (0.64) | GPBAR1ACACBKEAP1NFE2L2KDM5A | |
| SCHEMBL1389807 | 0.83 | GPBAR1 (0.69) | GPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593426-B1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | HOFFMANN LA ROCHE (CH) | 2014-08-20 | — | — | EP | claimed |