Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 12/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | XBP1 | P17861 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.46 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15949394 | 0.87 | HRH3 (0.61) | HRH3MAPTHTTGAASMN1; SMN2 | |
| SCHEMBL15949407 | 0.84 | HRH3 (0.49) | HRH3MAPTHTTGAASMN1; SMN2 | |
| SCHEMBL912391 | 0.81 | HRH3 (0.52) | HRH3MAPTHTTGAASMN1; SMN2 | |
| SCHEMBL913161 | 0.81 | HRH3 (0.52) | HRH3MAPTHTTGAASMN1; SMN2 | |
| SCHEMBL15949421 | 0.80 | MAPT (0.46) | HRH3MAPTHTTGAASMN1; SMN2 | |
| SCHEMBL15949411 | 0.77 | SMN1; SMN2 (0.50) | MAPTHTTGAASMN1; SMN2CYP3A4 | |
| SCHEMBL15949213 | 0.75 | HRH3 (0.64) | HRH3MAPTHTTGAASMN1; SMN2 | |
| SCHEMBL15949351 | 0.75 | GRM5 (0.39) | HRH3SMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL912159 | 0.72 | HRH3 (0.57) | HRH3MAPTHTTGAASMN1; SMN2 | |
| SCHEMBL15949231 | 0.72 | ALDH1A1 (0.43) | HRH3MAPTKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421823-B1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-01-14 | — | — | EP | disclosed |
| EP-2421825-B9 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-08-20 | — | — | EP | disclosed |
| EP-2421825-B1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-01-01 | — | — | EP | disclosed |