SCHEMBL15949449

SCHEMBL15949449

Cn1cc(I)c2ccc(C(=O)N3CC(N4CCN(C(=O)c5nccs5)CC4)C3)cc21

nearest known ligand 0.55

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MGLL Q99685 19/20 0.55
FAAH O00519 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL911995 0.86 MGLL (0.61) MGLLFAAH
SCHEMBL912970 0.85 MGLL (0.61) MGLLFAAH
SCHEMBL699320 0.84 MGLL (0.54) MGLLFAAH
SCHEMBL912077 0.83 MGLL (0.59) MGLLFAAH
SCHEMBL912896 0.83 MGLL (0.53) MGLLFAAH
SCHEMBL912233 0.83 MGLL (0.55) MGLLFAAH
SCHEMBL912377 0.81 MGLL (0.53) MGLLFAAH
SCHEMBL912243 0.81 MGLL (0.51) MGLLFAAH
SCHEMBL911363 0.79 MGLL (0.61) MGLLFAAH
SCHEMBL7874680 0.78 MGLL (0.59) MGLLFAAH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2421823-B1 AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS JANSSEN PHARMACEUTICA NV (BE) 2015-01-14 EP disclosed
EP-2421825-B9 AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS JANSSEN PHARMACEUTICA NV (BE) 2014-08-20 EP disclosed
EP-2421825-B1 AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS JANSSEN PHARMACEUTICA NV (BE) 2014-01-01 EP disclosed