Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 12/20 | 1.00 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | FAAH | O00519 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 7/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15949329 | 0.92 | MGLL (0.86) | MGLLPOLBHPGDALDH1A1 | |
| SCHEMBL15949435 | 0.92 | MGLL (0.85) | MGLLPOLBFAAHHPGDALDH1A1 | |
| SCHEMBL912466 | 0.91 | MGLL (0.84) | MGLLHPGDALDH1A1 | |
| SCHEMBL910872 | 0.86 | MGLL (0.81) | MGLLPOLBFAAH | |
| SCHEMBL912116 | 0.86 | MGLL (0.75) | MGLLPOLBHPGD | |
| SCHEMBL912004 | 0.86 | MGLL (0.75) | MGLLPOLBHPGD | |
| SCHEMBL15949218 | 0.84 | MGLL (0.73) | MGLLPOLBFAAHHPGDALDH1A1 | |
| SCHEMBL14648033 | 0.84 | MGLL (0.73) | MGLLPOLBFAAH | |
| SCHEMBL695655 | 0.83 | MGLL (1.00) | MGLLFAAHHPGDALDH1A1 | |
| SCHEMBL911857 | 0.82 | MGLL (0.68) | MGLLPOLBFAAHALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421823-B1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-01-14 | — | — | EP | disclosed |
| EP-2421825-B9 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-08-20 | — | — | EP | disclosed |
| EP-2421825-B1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-01-01 | — | — | EP | disclosed |