Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 14/20 | 0.68 |
| ▸ | FAAH | O00519 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 4/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15949358 | 0.85 | MGLL (0.58) | MGLLFAAHGAAMEN1ALDH1A1 | |
| SCHEMBL15949465 | 0.83 | MGLL (0.68) | MGLLFAAHHPGDGAAMEN1 | |
| SCHEMBL699684 | 0.82 | MGLL (0.54) | MGLLFAAH | |
| SCHEMBL912301 | 0.81 | MGLL (0.69) | MGLLFAAHHPGD | |
| SCHEMBL695655 | 0.81 | MGLL (1.00) | MGLLFAAHHPGDALDH1A1 | |
| SCHEMBL912122 | 0.80 | MGLL (0.84) | MGLLFAAHHPGDALDH1A1 | |
| SCHEMBL912499 | 0.79 | MGLL (0.67) | MGLLFAAHHPGD | |
| SCHEMBL15949424 | 0.79 | MGLL (0.85) | MGLLFAAHHPGD | |
| SCHEMBL15949445 | 0.79 | MGLL (0.85) | MGLLFAAHHPGDALDH1A1 | |
| SCHEMBL3773966 | 0.78 | MGLL (0.51) | MGLLFAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421823-B1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-01-14 | — | — | EP | disclosed |
| EP-2421825-B9 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-08-20 | — | — | EP | disclosed |
| EP-2421825-B1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-01-01 | — | — | EP | disclosed |