Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 3/20 | 0.49 |
| ▸ | CHRM1 known ✓ | P11229 | 3/20 | 0.49 |
| ▸ | CHRM4 known ✓ | P08173 | 2/20 | 0.49 |
| ▸ | CHRM5 known ✓ | P08912 | 2/20 | 0.49 |
| ▸ | CHRM3 known ✓ | P20309 | 2/20 | 0.49 |
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.49 |
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.46 |
| ▸ | KDM4A | O75164 | 2/20 | 0.66 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.66 |
| ▸ | HTT | P42858 | 5/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.60 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | APAF1 | O14727 | 2/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.60 |
| ▸ | BLM | P54132 | 1/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | CHAT | P28329 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL1594965 | 1.00 | KDM4A (0.66) | KDM4AKDM2AHTTKMT2AHSP90AA1 | |
| SCHEMBL13046320 | 0.98 | KDM4A (0.68) | KDM4AKDM2AHTTKMT2AHSP90AA1 | |
| SCHEMBL8080488 | 0.98 | KDM4A (0.68) | KDM4AKDM2AHTTKMT2AHSP90AA1 | |
| SCHEMBL13924754 | 0.98 | KDM4A (0.68) | KDM4AKDM2AHTTKMT2AHSP90AA1 | |
| SCHEMBL8080485 | 0.98 | KDM4A (0.68) | KDM4AKDM2AHTTKMT2AHSP90AA1 | |
| SCHEMBL13924728 | 0.90 | KDM4A (0.58) | KDM4AKDM2AHTTKMT2AHSP90AA1 | |
| SCHEMBL13924753 | 0.87 | KDM4A (0.55) | KDM4AKDM2AHTTKMT2AHSP90AA1 | |
| SCHEMBL13924727 | 0.84 | KDM4A (0.49) | KDM4AKDM2AHTTKMT2AMEN1 | |
| Bromide SCHEMBL9028285 | 0.84 | KMT2A (0.67) | HTTKMT2AHSP90AA1MEN1SMN1; SMN2 | |
| SCHEMBL13698933 | 0.83 | KDM4A (0.49) | KDM4AKDM2AHTTKMT2AHSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 91 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8050531-B2 | Dendrimer based terahertz generator | APPLIED RESEARCH AND PHOTONICS, INC. | 2011-11-01 | — | — | US | claimed |
| US-7919755-B2 | Dendrimer based electro-optic sensor | APPLIED RESEARCH AND PHOTONICS, INC. | 2011-04-05 | — | — | US | claimed |
| US-7854505-B2 | Passive and active photonic crystal structures and devices | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2010-12-21 | — | — | US | claimed |
| US-20090323014-A1 | PASSIVE AND ACTIVE PHOTONIC CRYSTAL STRUCTURES AND DEVICES | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2009-12-31 | — | — | US | claimed |
| US-20080128618-A1 | Dendrimer Based Electro-Optic Sensor | APPLIED RESEARCH AND PHOTONICS, INC. | 2008-06-05 | — | — | US | claimed |
| US-20080099698-A1 | Dendrimer Based Terahertz Generator | APPLIED RESEARCH AND PHOTONICS, INC. | 2008-05-01 | — | — | US | claimed |
| EP-0743574-B1 | Migration imaging members | XEROX CORP (US) | 2000-12-27 | — | — | EP | claimed |
| EP-0743573-B1 | Method for obtaining image contrast migration imaging members | XEROX CORP (US) | 2000-09-06 | — | — | EP | claimed |
| EP-0615855-B1 | Recording sheets containing pyridinium and/or piperazinum compounds | XEROX CORP (US) | 1997-05-14 | — | — | EP | claimed |
| EP-0743573-A2 | Method for obtaining image contrast migration imaging members | XEROX CORPORATION (US) | 1996-11-20 | — | — | EP | claimed |
| EP-0743574-A2 | Migration imaging members | XEROX CORPORATION (US) | 1996-11-20 | — | — | EP | claimed |
| US-5563014-A | SOFTENABLE LAYER CONTAINIG PHOTOSENSITIVE MARKING MATERIAL; TRANSPARENTIZING AGENT | XEROX CORPORATION (US) | 1996-10-08 | — | — | US | claimed |
| US-5514505-A | SELECTIVE TRANSPARENTIZATION OF PHOTOSENSITIVE MIGRATION MARKING PARTICLES EMBEDDED NEAR THE SURFACE OF A SOFTENABLE LAYER SUPPORTED BY AN ELECTROCONDUCTIVE SUBSTRATE | XEROX CORPORATION (US) | 1996-05-07 | — | — | US | claimed |
| US-5441795-A | Piperazinium compounds | XEROX CORPORATION (US) | 1995-08-15 | — | — | US | claimed |
| EP-0615855-A1 | Recording sheets containing pyridinium and/or piperazinum compounds | XEROX CORPORATION (US) | 1994-09-21 | — | — | EP | claimed |
| US-11884956-B2 | Methods for detecting mycobacteria with solvatochromic dye conjugates | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2024-01-30 | — | — | US | disclosed |
| US-20190169671-A1 | Methods for Detecting Mycobacteria with Solvatochromic Dye Conjugates | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2019-06-06 | — | — | US | disclosed |
| US-5514505-A | SELECTIVE TRANSPARENTIZATION OF PHOTOSENSITIVE MIGRATION MARKING PARTICLES EMBEDDED NEAR THE SURFACE OF A SOFTENABLE LAYER SUPPORTED BY AN ELECTROCONDUCTIVE SUBSTRATE | XEROX CORPORATION (US) | 1996-05-07 | — | — | US | disclosed |
| US-5441795-A | Piperazinium compounds | XEROX CORPORATION (US) | 1995-08-15 | — | — | US | disclosed |
| EP-0615855-A1 | Recording sheets containing pyridinium and/or piperazinum compounds | XEROX CORPORATION (US) | 1994-09-21 | — | — | EP | disclosed |