Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 5/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.46 |
| ▸ | PRKCG | P05129 | 1/20 | 0.36 |
| ▸ | PRKCA | P17252 | 1/20 | 0.36 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | SLC22A8 | Q8TCC7 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | GLA | P06280 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | CASP1 | P29466 | 2/20 | 0.33 |
| ▸ | CASP7 | P55210 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13259272 | 0.78 | KDM4E (0.36) | KDM4EMAPTL3MBTL1ALDH1A1HPGD | |
| SCHEMBL21527274 | 0.75 | KDM4E (0.34) | KDM4EMAPTL3MBTL1 | |
| SCHEMBL2044812 | 0.75 | PRKCG (0.36) | PRKCGPRKCAPRKCDKDM4EMAPT | |
| SCHEMBL1506602 | 0.75 | CYP3A4 (0.36) | KDM4EMAPTL3MBTL1ALDH1A1 | |
| SCHEMBL29746488 | 0.75 | PDCD1 (0.34) | KDM4EMAPTL3MBTL1ATM | |
| SCHEMBL13259279 | 0.75 | PDCD1 (0.34) | KDM4EMAPTL3MBTL1ATM | |
| SCHEMBL13259202 | 0.74 | KDM4E (0.41) | PRKCGPRKCAPRKCDKDM4EMAPT | |
| SCHEMBL30047413 | 0.72 | BCL2L1 (0.47) | ESR1ESR2KDM4ESLC22A8MAPK1 | |
| SCHEMBL30543188 | 0.70 | BCL2L1 (0.48) | PRKCGPRKCAPRKCDMAOADRD2 | |
| SCHEMBL9901389 | 0.70 | BCL2L1 (0.48) | PRKCGPRKCAPRKCDMAOADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3255993-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | Merck Sharp & Dohme Corp. (US) | 2017-12-20 | — | — | EP | disclosed |
| WO-2016130444-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME CORP. (US) | 2016-08-18 | — | — | WO | disclosed |
| EP-2956142-A2 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | Merck Sharp & Dohme Corp. (US) | 2015-12-23 | — | — | EP | disclosed |
| WO-2014126944-A2 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME CORP. (US) | 2014-08-21 | — | — | WO | disclosed |