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PRKCG

Protein kinase C gamma type · P05129 · PRKCG on Sugi Atlas →

92,733 patent compounds predicted against PRKCG, 67,964 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
Balanol Balanol (SCHEMBL62128) 1.00 17/20
Balanol Balanol (SCHEMBL62129) 1.00 17/20
Staurosporine Staurosporine (SCHEMBL8156) 1.00 10/20
Staurosporine Staurosporine (SCHEMBL8157) 1.00 10/20
SCHEMBL117745 SCHEMBL117745 0.56 7/20
Phorbol Phorbol (SCHEMBL72895) 0.62 6/20
SCHEMBL115053 SCHEMBL115053 0.56 6/20
Fasudil Fasudil (SCHEMBL4674) 1.00 5/20
Phorbol Myristate Acetate Phorbol Myristate Acetate (SCHEMBL115567) 1.00 5/20
SCHEMBL123495 SCHEMBL123495 1.00 5/20
SCHEMBL123496 SCHEMBL123496 1.00 5/20
SCHEMBL162855 SCHEMBL162855 1.00 5/20
SCHEMBL190590 SCHEMBL190590 1.00 5/20
SCHEMBL9306 SCHEMBL9306 0.89 5/20
SCHEMBL9305 SCHEMBL9305 0.74 5/20
SCHEMBL190415 SCHEMBL190415 0.63 5/20
SCHEMBL82376 SCHEMBL82376 0.63 5/20
SCHEMBL78989 SCHEMBL78989 0.62 5/20
Phorbol Phorbol (SCHEMBL64353) 0.62 5/20
SCHEMBL190414 SCHEMBL190414 0.62 5/20

Clinical trials — most relevant to PRKCG by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Short-Term Metformin Use in Young, Healthy Adults: Impacts on Exercise Capacity PHASE4COMPLETED
L-arginine Treatment in Mild Hypertension PHASE4UNKNOWN
Efficacy and Safety of Endoxifen in Bipolar I Disorder Patients PHASE3ACTIVE_NOT_RECRUITING
Evaluate Efficacy and Safety of Endoxifen in Bipolar I Disorder Patients PHASE3COMPLETED
Mitochondrial Oxidation and Insulin Resistance in Burn Patients Treated With Fenofibrate PHASE2/PHASE3WITHDRAWN
PKC412 and 5-Azacytidine PHASE1/PHASE2COMPLETED
Perfusion by Arterial Spin Labelling Following Single Dose Tadalafil in Small Vessel Disease (PASTIS) Trial PHASE2COMPLETED
The Phosphodiesterase 4 Inhibitor Roflumilast as an Adjunct to Antidepressants in Major Depressive Disorder Patients PHASE1/PHASE2WITHDRAWN
I/II Phase Study Evaluating M1774 in Combination With Fulvestrant in HR+ and HER2- Advanced Breast Cancers PHASE1/PHASE2NOT_YET_RECRUITING
Theophylline Treatment for Pseudohypoparathyroidism - Children 2-12 Years Old PHASE2ACTIVE_NOT_RECRUITING
Sirolimus and Gold Sodium Thiomalate in Treating Patients With Advanced Squamous Non-Small Cell Lung Cancer PHASE1WITHDRAWN
Temsirolimus and Sorafenib in Advanced Hepatocellular Carcinoma PHASE1COMPLETED
Pre-Surgical Trial of the Combination of Metformin and Atorvastatin in Newly Diagnosed Operable Breast Cancer EARLY_PHASE1COMPLETED
Free Fatty Acid Induced Insulin Resistance nanCOMPLETED
Possible Diagnostic Protein Markers in Schistosoma Related Bladder Diseases. nanNOT_YET_RECRUITING
Defective Atypical Protein Kinase C (PKC) Activation in Diabetes and Metabolic Syndrome nanCOMPLETED
Intravenous Terbutaline in Severe Status Asthmaticus nanUNKNOWN
Duality of Lipids: the Athlete's Paradox nanCOMPLETED
Role of Nitric Oxide in Diabetic Patients With Erectile Dysfunction nanCOMPLETED
Ischemic Preconditioning to Prevent Acute Kidney Injury nanCOMPLETED
Skeletal Muscle Mitochondrial Abnormalities and the Metabolic Syndrome in PAH nanCOMPLETED
Effect of Adenovirus E1A Oncogene on DNA Replication Dynamics nanUNKNOWN
Effect of Age on Glucose and Lipid Metabolism nanCOMPLETED
Glycine and Magnesium+Thiamine for the Treatment of Primary Ciliary Dyskinesia nanRECRUITING
The Phosphodiesterase-3 Inhibitor Cilostazol as an Adjunctive to Antidepressants in Patients With Major Depressive Disorder. nanCOMPLETED
Fat Induced Insulin Resistance and Atherosclerosis nanCOMPLETED
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes nanCOMPLETED
Glutamate Supplementation in Young Men nanCOMPLETED
Effect of Esterogen Receptor Modulator on Gene in Bipolar Diseas nanNOT_YET_RECRUITING
Glucagon Like Peptide-1 in Remote Ischemic Conditioning nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a PRKCG binder may also engage these)

ProteinNameSimilarity
Q4R4U2 — 1.000 Q4R4U2 →
P63318 — 1.000 P63318 →
P63319 — 1.000 P63319 →
P10829 — 1.000 P10829 →
P05128 — 1.000 P05128 →
A8KBH6 — 0.995 A8KBH6 →
PRKCA Protein kinase C alpha type 0.994 landscape →
PRKCB Protein kinase C beta type 0.993 landscape →
Q16974 — 0.993 Q16974 →
P13678 — 0.992 P13678 →
P04409 — 0.991 P04409 →
P34885 — 0.991 P34885 →
P05696 — 0.990 P05696 →
P10102 — 0.990 P10102 →
PRKCE Protein kinase C epsilon type 0.989 landscape →
P09216 — 0.988 P09216 →
P10830 — 0.988 P10830 →
P68404 — 0.988 P68404 →
P05126 — 0.988 P05126 →
P16054 — 0.987 P16054 →
P05772 — 0.987 P05772 →
P20444 — 0.987 P20444 →
Q16975 — 0.987 Q16975 →
Q8R4U9 — 0.987 Q8R4U9 →
Q7LZQ8 — 0.987 Q7LZQ8 →
RPS6KA1 Ribosomal protein S6 kinase alpha-1 0.986 landscape →
P23298 — 0.986 P23298 →
P05130 — 0.986 P05130 →
Q63531 — 0.985 Q63531 →
Q64617 — 0.985 Q64617 →