Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | DRD4 | P21917 | 5/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.54 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
| ▸ | PTGIR | P43119 | 1/20 | 0.49 |
| ▸ | HRH2 | P25021 | 1/20 | 0.47 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | CMA1 | P23946 | 1/20 | 0.46 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.46 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15399382 | 1.00 | SMN1; SMN2 (0.57) | SMN1; SMN2DRD4SIGMAR1DRD2DRD3 | |
| SCHEMBL2432513 | 0.85 | SMN1; SMN2 (0.58) | SMN1; SMN2DRD4SIGMAR1DRD2DRD3 | |
| SCHEMBL17304807 | 0.80 | SIGMAR1 (0.54) | SMN1; SMN2DRD4SIGMAR1PTGIRHRH2 | |
| SCHEMBL2918073 | 0.79 | SIGMAR1 (0.57) | SMN1; SMN2DRD4SIGMAR1PTGIRHRH2 | |
| SCHEMBL18205232 | 0.79 | SIGMAR1 (0.57) | SMN1; SMN2DRD4SIGMAR1DRD2DRD3 | |
| SCHEMBL2916777 | 0.79 | DRD4 (0.57) | SMN1; SMN2DRD4SIGMAR1PTGIRHRH2 | |
| SCHEMBL25262904 | 0.79 | DRD4 (0.51) | SMN1; SMN2DRD4SIGMAR1DRD2DRD3 | |
| SCHEMBL30452961 | 0.79 | DRD4 (0.51) | SMN1; SMN2DRD4SIGMAR1DRD2DRD3 | |
| SCHEMBL30454225 | 0.79 | DRD4 (0.51) | SMN1; SMN2DRD4SIGMAR1DRD2DRD3 | |
| SCHEMBL30454820 | 0.79 | DRD4 (0.51) | SMN1; SMN2DRD4SIGMAR1DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2867238-B1 | PHENYL AMINO PYRIMIDINE BICYCLIC COMPOUNDS AND USES THEREOF | YM BIOSCIENCES AUSTRALIA PTY (AU) | 2017-08-09 | — | — | EP | disclosed |
| US-8809359-B2 | Phenyl amino pyrimidine bicyclic compounds and uses thereof | YM BIOSCIENCES AUSTRALIA PTY LTD (US) | 2014-08-19 | — | — | US | disclosed |