Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.40 |
| ▸ | KIF11 | P52732 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.35 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.35 |
| ▸ | PLOD1 | Q02809 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL369979 | 0.79 | GPBAR1 (0.44) | GPBAR1KIF11GAAALDH1A1CYP1A2 | |
| SCHEMBL364069 | 0.79 | GPBAR1 (0.44) | GPBAR1KIF11GAAALDH1A1CYP1A2 | |
| SCHEMBL363699 | 0.79 | GPBAR1 (0.44) | GPBAR1KIF11GAAALDH1A1CYP1A2 | |
| SCHEMBL9321480 | 0.68 | GAA (0.50) | GPBAR1RAB9AGAAALDH1A1CYP1A2 | |
| SCHEMBL9321485 | 0.68 | GAA (0.50) | GPBAR1RAB9AGAAALDH1A1CYP1A2 | |
| SCHEMBL368448 | 0.66 | GPBAR1 (0.76) | GPBAR1GAAALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL363952 | 0.66 | GPBAR1 (0.76) | GPBAR1GAAALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL368449 | 0.66 | GPBAR1 (0.76) | GPBAR1GAAALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL9324776 | 0.65 | KDM4E (0.46) | GPBAR1GAAALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL9324768 | 0.65 | KDM4E (0.46) | GPBAR1GAAALDH1A1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593426-B1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | HOFFMANN LA ROCHE (CH) | 2014-08-20 | — | — | EP | disclosed |