SCHEMBL15958992

SCHEMBL15958992

O/N=C(\CC(c1ccccc1)c1ccc(Br)cc1)c1ccnc(CI)c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GPBAR1 Q8TDU6 6/20 0.47
HTR2A P28223 2/20 0.35
CYP19A1 P11511 4/20 0.33
SLC6A3 Q01959 5/20 0.32
SLC6A2 P23975 4/20 0.32
SLC6A4 P31645 4/20 0.32
CHRM2 P08172 2/20 0.32
CHRM1 P11229 2/20 0.32
DRD1 P21728 2/20 0.32
HRH1 P35367 2/20 0.32
KCNH2 Q12809 2/20 0.32
HRH3 Q9Y5N1 2/20 0.32
LMNA P02545 1/20 0.32
CYP2D6 P10635 1/20 0.32
NFKB1 P19838 1/20 0.32
THPO P40225 1/20 0.32
HIF1A Q16665 1/20 0.32
HTR2C P28335 1/20 0.32
SCN1A P35498 1/20 0.32
SCN2A Q99250 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL364472 0.86 GPBAR1 (0.49) GPBAR1HTR2ACYP19A1SLC6A3SLC6A2
SCHEMBL10240912 0.86 GPBAR1 (0.49) GPBAR1HTR2ACYP19A1SLC6A3SLC6A2
SCHEMBL1389558 0.86 GPBAR1 (0.49) GPBAR1HTR2ACYP19A1SLC6A3SLC6A2
SCHEMBL368976 0.80 GPBAR1 (0.70) GPBAR1HTR2ACYP19A1SLC6A3SLC6A2
SCHEMBL368974 0.80 GPBAR1 (0.70) GPBAR1HTR2ACYP19A1SLC6A3SLC6A2
SCHEMBL368975 0.80 GPBAR1 (0.70) GPBAR1HTR2ACYP19A1SLC6A3SLC6A2
SCHEMBL365184 0.77 GPBAR1 (0.46) GPBAR1HTR2ACYP19A1SLC6A3SLC6A2
SCHEMBL1389631 0.77 GPBAR1 (0.46) GPBAR1HTR2ACYP19A1SLC6A3SLC6A2
SCHEMBL1389633 0.77 GPBAR1 (0.46) GPBAR1HTR2ACYP19A1SLC6A3SLC6A2
SCHEMBL1389706 0.75 GPBAR1 (0.61) GPBAR1HTR2ASLC6A3SLC6A2SLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2593426-B1 1-HYDROXYIMINO-3-PHENYL-PROPANES HOFFMANN LA ROCHE (CH) 2014-08-20 EP disclosed