Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 7/20 | 0.61 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.35 |
| ▸ | CTSA | P10619 | 6/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.32 |
| ▸ | DRD1 | P21728 | 2/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.32 |
| ▸ | HRH1 | P35367 | 2/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | THPO | P40225 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | SCN1A | P35498 | 1/20 | 0.32 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL361804 | 1.00 | GPBAR1 (0.61) | GPBAR1NR3C2CTSACHRM2CHRM1 | |
| SCHEMBL10241034 | 1.00 | GPBAR1 (0.61) | GPBAR1NR3C2CTSACHRM2CHRM1 | |
| SCHEMBL363961 | 0.89 | GPBAR1 (0.74) | GPBAR1NR3C2CTSACHRM2CHRM1 | |
| SCHEMBL1389779 | 0.89 | GPBAR1 (0.74) | GPBAR1NR3C2CTSACHRM2CHRM1 | |
| SCHEMBL10241033 | 0.89 | GPBAR1 (0.74) | GPBAR1NR3C2CTSACHRM2CHRM1 | |
| SCHEMBL364580 | 0.89 | GPBAR1 (0.74) | GPBAR1NR3C2CTSACHRM2CHRM1 | |
| SCHEMBL1389777 | 0.89 | GPBAR1 (0.74) | GPBAR1NR3C2CTSACHRM2CHRM1 | |
| SCHEMBL1389615 | 0.89 | GPBAR1 (0.74) | GPBAR1NR3C2CTSACHRM2CHRM1 | |
| SCHEMBL1389405 | 0.88 | GPBAR1 (0.57) | GPBAR1CTSAHTR2AMGAMGAA | |
| SCHEMBL363294 | 0.88 | GPBAR1 (0.57) | GPBAR1CTSAHTR2AMGAMGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593426-B1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | HOFFMANN LA ROCHE (CH) | 2014-08-20 | — | — | EP | disclosed |
| US-8765730-B2 | 1-hydroxyimino-3-phenyl-propanes | Hoffmann-La Roche Inc (US) | 2014-07-01 | — | — | US | disclosed |
| US-20120010190-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120010190-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | GPBAR1, GPR119, ADRB1 | GPBAR1 1/4885NR3C2 232/4885CTSA 3225/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.