Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.35 |
| ▸ | WDR5 | P61964 | 5/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.34 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.34 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | RXRB | P28702 | 1/20 | 0.33 |
| ▸ | RXRG | P48443 | 1/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.33 |
| ▸ | PTGES | O14684 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HSPA9 | P38646 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15961238 | 1.00 | SIRT2 (0.35) | SIRT2WDR5ALDH1A1LMNAPOLB | |
| SCHEMBL15976459 | 0.87 | BACE1 (0.47) | SIRT2ALDH1A1LMNAMAPT | |
| SCHEMBL10198037 | 0.84 | LMNA (0.38) | SIRT2ALDH1A1LMNAPOLBKMT2A | |
| SCHEMBL2892930 | 0.83 | BACE1 (0.35) | — | |
| SCHEMBL568438 | 0.81 | LMNA (0.33) | SIRT2ALDH1A1LMNAKMT2AGAA | |
| SCHEMBL8516276 | 0.67 | BACE2 (0.41) | WDR5KMT2AMAPT | |
| SCHEMBL8516273 | 0.67 | BACE2 (0.41) | WDR5KMT2AMAPT | |
| SCHEMBL8516270 | 0.67 | BACE2 (0.41) | WDR5KMT2AMAPT | |
| SCHEMBL299015 | 0.67 | BACE1 (0.44) | WDR5ALDH1A1GAAMAPT | |
| SCHEMBL299014 | 0.67 | BACE1 (0.44) | WDR5ALDH1A1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8815881-B2 | 1,4,5,6-tetrahydro-pyrimidin-2-ylamine compounds | HOFFMANN-LA ROCHE INC. (US) | 2014-08-26 | — | — | US | disclosed |