Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | FAAH | O00519 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.46 |
| ▸ | FABP4 | P15090 | 2/20 | 0.45 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.43 |
| ▸ | GRK5 | P34947 | 1/20 | 0.43 |
| ▸ | CDK8 | P49336 | 1/20 | 0.43 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15967788 | 1.00 | HSD11B1 (0.53) | HSD11B1ALDH1A1GAAKDM4EKMT2A | |
| SCHEMBL14556085 | 0.87 | KCNH2 (0.51) | HSD11B1ALDH1A1GAAKDM4EKMT2A | |
| SCHEMBL15967633 | 0.87 | KCNH2 (0.51) | HSD11B1ALDH1A1GAAKDM4EKMT2A | |
| SCHEMBL16584536 | 0.85 | HSD11B1 (0.49) | HSD11B1ALDH1A1GAAKDM4EFAAH | |
| SCHEMBL16584538 | 0.85 | HSD11B1 (0.49) | HSD11B1ALDH1A1GAAKDM4EFAAH | |
| SCHEMBL15665132 | 0.82 | CYP2D6 (0.46) | ALDH1A1GAAKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL15923278 | 0.82 | CYP2D6 (0.46) | ALDH1A1GAAKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL27952439 | 0.82 | CYP2D6 (0.46) | ALDH1A1GAAKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL16584584 | 0.81 | KDM4E (0.48) | HSD11B1ALDH1A1GAAKDM4EFAAH | |
| SCHEMBL16584585 | 0.81 | KDM4E (0.48) | HSD11B1ALDH1A1GAAKDM4EFAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2729141-B1 | CYCLIC AMINE DERIVATIVES AS EP4 RECEPTOR AGONISTS | Rottapharm Biotech Srl (IT) | 2015-12-09 | — | — | EP | disclosed |
| US-9120824-B2 | Cyclic amine derivatives as EP4 receptor agonists | ROTTAPHARM BIOTECH S.R.L. (IT) | 2015-09-01 | — | — | US | disclosed |
| US-9120824-B2 | Cyclic amine derivatives as EP4 receptor agonists | ROTTAPHARM BIOTECH S.R.L. (IT) | 2015-09-01 | — | — | US | disclosed |
| US-9120824-B2 | Cyclic amine derivatives as EP4 receptor agonists | ROTTAPHARM BIOTECH S.R.L. (IT) | 2015-09-01 | — | — | US | disclosed |
| US-20140243373-A1 | CYCLIC AMINE DERIVATIVES AS EP4 RECEPTOR AGONISTS | ROTTAPHARM S.P.A. (IT) | 2014-08-28 | — | — | US | disclosed |
| US-20140243373-A1 | CYCLIC AMINE DERIVATIVES AS EP4 RECEPTOR AGONISTS | ROTTAPHARM S.P.A. (IT) | 2014-08-28 | — | — | US | disclosed |
| US-20140243373-A1 | CYCLIC AMINE DERIVATIVES AS EP4 RECEPTOR AGONISTS | ROTTAPHARM S.P.A. (IT) | 2014-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140243373-A1 | CYCLIC AMINE DERIVATIVES AS EP4 RECEPTOR AGONISTS | PTGER4, PTGER1, PTGIR | HSD11B1 2064/4885ALDH1A1 1634/4885GAA 3451/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.