8-Aminoquinoline

8-Aminoquinoline

SCHEMBL159694

Nc1cccc2cccnc12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.61
TDP1 Q9NUW8 3/20 0.61
MAPT P10636 3/20 0.61
KDM4E B2RXH2 3/20 0.61
MMP2 P08253 2/20 0.61
TSHR P16473 2/20 0.61
CYP3A4 P08684 2/20 0.61
HSP90AA1 P07900 2/20 0.61
GMNN O75496 1/20 0.61
TP53 P04637 1/20 0.61
CYP2D6 P10635 1/20 0.61
MMP9 P14780 1/20 0.61
ALOX15 P16050 1/20 0.61
NFKB1 P19838 1/20 0.61
MMP8 P22894 1/20 0.61
CCR1 P32246 1/20 0.61
THPO P40225 1/20 0.61
MTOR P42345 1/20 0.61
HTT P42858 1/20 0.61
MMP13 P45452 1/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
8-Aminoquinoline SCHEMBL29735354 1.00 LMNA (0.61) LMNATDP1MAPTKDM4EMMP2
8-Aminoquinoline SCHEMBL11260984 0.98 LMNA (0.58) LMNATDP1MAPTKDM4EMMP2
8-Aminoquinoline SCHEMBL27411912 0.98 LMNA (0.58) LMNATDP1MAPTKDM4EMMP2
8-Aminoquinoline SCHEMBL28534121 0.96 LMNA (0.56) LMNATDP1MAPTKDM4EMMP2
8-Aminoquinoline SCHEMBL28187659 0.96 LMNA (0.56) LMNATDP1MAPTKDM4EMMP2
8-Aminoquinoline SCHEMBL28534120 0.92 LMNA (0.52) LMNATDP1MAPTKDM4EMMP2
8-Aminoquinoline SCHEMBL27567507 0.92 LMNA (0.52) LMNATDP1MAPTKDM4EMMP2
8-Aminoquinoline SCHEMBL28284182 0.90 LMNA (0.52) LMNATDP1MAPTKDM4EMMP2
8-Aminoquinoline SCHEMBL28073955 0.90 LMNA (0.50) LMNATDP1MAPTKDM4EMMP2
8-Aminoquinoline SCHEMBL29286899 0.88 PARP1 (0.51) LMNATDP1MAPTKDM4EMMP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 5450 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122094672-A Method for treating and preventing non-viral tick-borne diseases and symptoms thereof 2026-05-26 CN claimed
CN-122010931-A Synthesis method and application of asymmetric 1, 10-phenanthroline 首都师范大学 2026-05-12 CN claimed
EP-4698165-A1 METHODS FOR THE TREATMENT AND PREVENTION OF NON-VIRAL TICK-BORNE DISEASES AND SYMPTOMS THEREOF 60 Degrees Pharmaceuticals, Inc. (US) 2026-02-25 EP claimed
EP-3625238-B1 NOVEL SPIRO-LACTAM COMPOUNDS, PROCESS AND USES THEREOF UNIV DE COIMBRA (PT) 2025-11-26 EP claimed
WO-2025217208-A1 CHEMICAL MECHANICAL PLANARIZATION POLISHING FOR INTERCONNECTS DIFFUSION BARRIER MATERIALS VERSUM MATERIALS US, LLC (US) 2025-10-16 WO claimed
CN-119980384-A Anchor piece containing wear-resistant coating for high-speed rail and preparation method thereof 江苏鼎铭峰业机械制造有限公司 2025-05-13 CN claimed
CN-115819338-B Preparation method of o-tertiary butyl amino benzamide derivative 常州大学 2025-04-25 CN claimed
CN-119859216-A Polar functionalized conjugated diene polymer and preparation method thereof 东华大学 2025-04-22 CN claimed
CN-119775997-A Quinoline modified nano white carbon black zinc ion fluorescent probe based on surface imprinting technology and application thereof 江苏海洋大学 2025-04-08 CN claimed
CN-119432392-A Soil restoration agent for improving acidified soil and manufacturing method thereof 广东省农业科学院 2025-02-14 CN claimed
US-4681814-A COMPLEX FORMING ORGANIC COMPOUND SURFACE LAYER LEHIGH UNIVERSITY (US) 1987-07-21 US claimed
US-4563253-A COMPLEXING ORGANIC COMPOUND WITH THIN OXIDE LAYER LEHIGH UNIVERSITY (US) 1986-01-07 US claimed
EP-0152379-A2 Process for preparing pharmaceutical compositions containing unilamellar liposomes CIBA-GEIGY AG (CH) 1985-08-21 EP claimed
EP-0035856-B1 PHARMACEUTICAL AND DIETARY COMPOSITIONS EFAMOL LIMITED (GB) 1984-07-04 EP claimed
US-4416872-A INTERRUPTING LIFE CYCLE OF THE PARASITE IN LIVER OF HOST THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) 1983-11-22 US claimed
US-4302459-A Liposome carriers in leishmaniasis chemotherapy with 8-aminoquinoline derivatives THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) 1981-11-24 US claimed
EP-0037175-A1 Pharmaceutical compositions EFAMOL LIMITED (GB) 1981-10-07 EP claimed
EP-0035856-A2 Pharmaceutical and dietary compositions EFAMOL LIMITED (GB) 1981-09-16 EP claimed
US-4033716-A Transfer printing process for hydrophilic fibrous material CIBA-GEIGY AG (CH) 1977-07-05 US claimed
US-3956420-A CPOLYOLEFIN COMPOSITION FOR ELECTRICAL INSULATIONFERROCENE, 8-SUBSTITUTED QUINOLINE DAINICHI-NIPPON CABLES, LTD. (JA) 1976-05-11 US claimed