Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | STAT3 | P40763 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | S100A4 | P26447 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20455722 | 0.87 | GLA (0.45) | GLAL3MBTL1STAT3ALDH1A1MAPT | |
| SCHEMBL690833 | 0.87 | STAT3 (0.40) | STAT3ALDH1A1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL15971922 | 0.87 | L3MBTL1 (0.40) | GLAL3MBTL1STAT3ALDH1A1MAPT | |
| SCHEMBL18101 | 0.83 | STAT3 (0.37) | STAT3ALDH1A1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL24194808 | 0.82 | STAT3 (0.39) | STAT3ALDH1A1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL16572522 | 0.82 | STAT3 (0.36) | STAT3ALDH1A1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL30455226 | 0.81 | GLA (0.38) | GLAL3MBTL1STAT3ALDH1A1MAPT | |
| SCHEMBL10950116 | 0.81 | STAT3 (0.36) | STAT3ALDH1A1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL29906298 | 0.81 | GLA (0.40) | GLAL3MBTL1STAT3ALDH1A1MAPT | |
| SCHEMBL2578056 | 0.78 | PDE9A (0.36) | STAT3ALDH1A1TDP1CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10966980-B2 | Pyrrolo[2,3-d]pyrimidine derivatives | PFIZER INC. (US) | 2021-04-06 | — | — | US | disclosed |
| EP-3180344-B1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES USEFUL FOR INHIBITING JANUS KINASE | PFIZER (US) | 2019-09-18 | — | — | EP | disclosed |
| EP-3290421-B1 | COMBINATION OF PYRROLO [2, 3 -D]PYRIMIDINE DERIVATIVES WITH ONE OR MORE ADDITIONAL AGENTS AS INHIBITORS OF JANUS- RELATED KINASES (JAK) | PFIZER (US) | 2019-01-02 | — | — | EP | disclosed |
| EP-3290421-A1 | COMBINATION OF PYRROLO [2, 3 -D]PYRIMIDINE DERIVATIVES WITH ONE OR MORE ADDITIONAL AGENTS AS INHIBITORS OF JANUS- RELATED KINASES (JAK) | Pfizer Inc (US) | 2018-03-07 | — | — | EP | disclosed |
| EP-2958921-B1 | PYRROLO [2, 3 -D]PYRIMIDINE DERIVATIVES AS INHIBITORS OF JANUS KINASES (JAK) | PFIZER (US) | 2017-09-20 | — | — | EP | disclosed |
| EP-3180344-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES USEFUL FOR INHIBITING JANUS KINASE | Pfizer Inc (US) | 2017-06-21 | — | — | EP | disclosed |
| US-9549929-B2 | Pyrrolo[2,3-D]pyrimidine derivatives | PFIZER INC. (US) | 2017-01-24 | — | — | US | disclosed |
| US-9545405-B2 | Pyrrolo[2,3-D]pyrimidine derivatives | PFIZER INC. (US) | 2017-01-17 | — | — | US | disclosed |
| US-20160045508-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES | PFIZER INC. (US) | 2016-02-18 | — | — | US | disclosed |
| WO-2016024185-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES USEFUL FOR INHIBITING JANUS KINASE | PFIZER INC. (US) | 2016-02-18 | — | — | WO | disclosed |
| EP-2958921-A1 | PYRROLO [2, 3 -D]PYRIMIDINE DERIVATIVES AS INHIBITORS OF JANUS- RELATED KINASES (JAK) | Pfizer Inc. (US) | 2015-12-30 | — | — | EP | disclosed |
| US-20150246048-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES | PFIZER INC. | 2015-09-03 | — | — | US | disclosed |
| US-20150225408-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES | PFIZER INC. | 2015-08-13 | — | — | US | disclosed |
| US-9035074-B2 | Pyrrolo[2,3-D]pyrimidine derivatives | PFIZER INC. (US) | 2015-05-19 | — | — | US | disclosed |
| WO-2014128591-A1 | PYRROLO [2, 3 -D]PYRIMIDINE DERIVATIVES AS INHIBITORS OF JANUS- RELATED KINASES (JAK) | PFIZER INC. (US) | 2014-08-28 | — | — | WO | disclosed |
| US-20140243312-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES | PFIZER INC. (US) | 2014-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150225408-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES | JAK3, JAK1, JAK2 | GLA 4834/4885L3MBTL1 4224/4885STAT3 30/4885 |
| US-20160045508-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES | JAK3, JAK1, JAK2 | GLA 4790/4885L3MBTL1 4148/4885STAT3 26/4885 |
| US-10966980-B2 | Pyrrolo[2,3-d]pyrimidine derivatives | JAK3, JAK1, JAK2 | GLA 4790/4885L3MBTL1 4148/4885STAT3 26/4885 |
| US-20150246048-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES | JAK3, JAK1, JAK2 | GLA 4834/4885L3MBTL1 4224/4885STAT3 30/4885 |
| US-20140243312-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES | JAK3, JAK1, JAK2 | GLA 4834/4885L3MBTL1 4224/4885STAT3 30/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.