Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 13/20 | 0.33 |
| ▸ | JAK1 | P23458 | 13/20 | 0.33 |
| ▸ | TYK2 | P29597 | 13/20 | 0.33 |
| ▸ | JAK3 | P52333 | 13/20 | 0.33 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2184103 | 0.92 | JAK2 (0.35) | JAK2JAK1TYK2JAK3ACVR1 | |
| SCHEMBL101162 | 0.91 | GRM4 (0.34) | — | |
| SCHEMBL15970036 | 0.79 | CHUK (0.31) | — | |
| SCHEMBL101210 | 0.78 | JAK2 (0.33) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL4088916 | 0.74 | JAK2 (0.36) | JAK2JAK1TYK2JAK3ACVR1 | |
| SCHEMBL99248 | 0.70 | JAK2 (0.35) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL99958 | 0.69 | AURKB (0.59) | JAK2JAK1TYK2JAK3ACVR1 | |
| SCHEMBL101161 | 0.69 | GRM4 (0.34) | — | |
| SCHEMBL98816 | 0.67 | — | — | |
| SCHEMBL2148207 | 0.66 | DGAT1 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140243360-A1 | Heteroaryl Substituted Pyrrolo[2,3-B] Pyridines And Pyrrolo[2,3-B] Pyrimidines As Janus Kinase Inhibitors | INCYTE CORPORATION (US) | 2014-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140243360-A1 | Heteroaryl Substituted Pyrrolo[2,3-B] Pyridines And Pyrrolo[2,3-B] Pyrimidines As Janus Kinase Inhibitors | JAK3, JAK1, JAK2 | JAK2 3/4885JAK1 2/4885TYK2 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.