Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 5/20 | 0.51 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.45 |
| ▸ | FAAH | O00519 | 3/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | MGLL | Q99685 | 1/20 | 0.42 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 2/20 | 0.41 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.41 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.41 |
| ▸ | MCTS1 | Q9ULC4 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | USP7 | Q93009 | 1/20 | 0.40 |
| ▸ | NOS1 | P29475 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15973385 | 0.90 | DHODH (0.52) | DHODHPARP1FAAHMGLLAVPR1B | |
| SCHEMBL17921462 | 0.89 | DHODH (0.56) | DHODHPARP1PSMB8JAK1CNR2 | |
| SCHEMBL24060220 | 0.85 | DHODH (0.54) | DHODHPARP1PSMB8CNR2LMNA | |
| SCHEMBL25939483 | 0.84 | DHODH (0.50) | DHODHPARP1PSMB8FAAHJAK1 | |
| SCHEMBL15974119 | 0.84 | DHODH (0.50) | DHODHPARP1PSMB8FAAHJAK1 | |
| SCHEMBL15973955 | 0.84 | DHODH (0.66) | DHODHFAAHMGLLCYP3A4CYP2D6 | |
| SCHEMBL25939468 | 0.82 | DHODH (0.46) | DHODHPARP1PSMB8FAAHJAK1 | |
| SCHEMBL15973293 | 0.82 | DHODH (0.46) | DHODHPARP1PSMB8FAAHJAK1 | |
| SCHEMBL23644574 | 0.80 | DHODH (0.51) | DHODHPARP1PSMB8FAAHAVPR1B | |
| SCHEMBL17921461 | 0.79 | DHODH (0.67) | DHODHPARP1CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3417850-A1 | TRISUBSTITUTED BENZOTRIAZOLE DERIVATIVES AS DIHYDROOROTATE OXYGENASE INHIBITORS | Aurigene Discovery Technologies Limited (IN) | 2018-12-26 | — | — | EP | claimed |
| EP-3019482-A2 | TRISUBSTITUTED BENZOTRIAZOLE DERIVATIVES AS DIHYDROOROTATE OXYGENASE INHIBITORS | Aurigene Discovery Technologies Limited (IN) | 2016-05-18 | — | — | EP | claimed |
| WO-2014128669-A2 | TRISUBSTITUTED BENZOTRIAZOLE DERIVATIVES AS DIHYDROOROTATE OXYGENASE INHIBITORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2014-08-28 | — | — | WO | claimed |
| US-11717512-B2 | Methods of use for trisubstituted benzotriazole derivatives | SERVIER PHARMACEUTICALS LLC (US) | 2023-08-08 | — | — | US | disclosed |
| US-11717512-B2 | Methods of use for trisubstituted benzotriazole derivatives | SERVIER PHARMACEUTICALS LLC (US) | 2023-08-08 | — | — | US | disclosed |
| EP-3915557-A1 | METHODS OF USE FOR TRISUBSTITUTED BENZOTRIAZOLE DERIVATIVES AS DIHYDROOROTATE OXYGENASE INHIBITORS | Aurigene Discovery Technologies Limited (IN) | 2021-12-01 | — | — | EP | disclosed |
| EP-3915557-A1 | METHODS OF USE FOR TRISUBSTITUTED BENZOTRIAZOLE DERIVATIVES AS DIHYDROOROTATE OXYGENASE INHIBITORS | Aurigene Discovery Technologies Limited (IN) | 2021-12-01 | — | — | EP | disclosed |
| US-11147801-B2 | Methods of use for trisubstituted benzotriazole derivatives as dihydroorotate oxygenase inhibitors | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2021-10-19 | — | — | US | disclosed |
| EP-3615027-B1 | METHODS OF USE FOR TRISUBSTITUTED BENZOTRIAZOLE DERIVATIVES AS DIHYDROOROTATE OXYGENASE INHIBITORS | AURIGENE DISCOVERY TECH LTD (IN) | 2021-07-14 | — | — | EP | disclosed |
| US-20210113531-A1 | METHODS OF USE FOR TRISUBSTITUTED BENZOTRIAZOLE DERIVATIVES | SERVIER PHARMACEUTICALS LLC | 2021-04-22 | — | — | US | disclosed |
| EP-3615027-A1 | METHODS OF USE FOR TRISUBSTITUTED BENZOTRIAZOLE DERIVATIVES AS DIHYDROOROTATE OXYGENASE INHIBITORS | Aurigene Discovery Technologies Limited (IN) | 2020-03-04 | — | — | EP | disclosed |
| US-20180021311-A1 | TRISUBSTITUTED BENZOTRIAZOLE DERIVATIVES AS DIHYDROOROTATE OXYGENASE INHIBITORS | AURIGENE ONCOLOGY LIMITED (IN) | 2018-01-25 | — | — | US | disclosed |
| US-20170224663-A1 | Methods of Use for Trisubstituted Benzotriazole Derivatives as Dihydroorotate Oxygenase Inhibitors | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2017-08-10 | — | — | US | disclosed |
| US-20170224663-A1 | Methods of Use for Trisubstituted Benzotriazole Derivatives as Dihydroorotate Oxygenase Inhibitors | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2017-08-10 | — | — | US | disclosed |
| US-9630932-B2 | Trisubstituted benzotriazole derivatives as dihydroorotate oxygenase inhibitors | Um Pharmauji Sdn. Bhd. (MY) | 2017-04-25 | — | — | US | disclosed |
| US-9630932-B2 | Trisubstituted benzotriazole derivatives as dihydroorotate oxygenase inhibitors | Um Pharmauji Sdn. Bhd. (MY) | 2017-04-25 | — | — | US | disclosed |
| US-20160200693-A1 | Trisubstituted Benzotriazole Derivatives as Dihydroorotate Oxygenase Inhibitors | Um Pharmauji Sdn. Bhd. (MY) | 2016-07-14 | — | — | US | disclosed |
| US-20160200693-A1 | Trisubstituted Benzotriazole Derivatives as Dihydroorotate Oxygenase Inhibitors | Um Pharmauji Sdn. Bhd. (MY) | 2016-07-14 | — | — | US | disclosed |
| EP-3019482-A2 | TRISUBSTITUTED BENZOTRIAZOLE DERIVATIVES AS DIHYDROOROTATE OXYGENASE INHIBITORS | Aurigene Discovery Technologies Limited (IN) | 2016-05-18 | — | — | EP | disclosed |
| WO-2014128669-A2 | TRISUBSTITUTED BENZOTRIAZOLE DERIVATIVES AS DIHYDROOROTATE OXYGENASE INHIBITORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2014-08-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180021311-A1 | TRISUBSTITUTED BENZOTRIAZOLE DERIVATIVES AS DIHYDROOROTATE OXYGENASE INHIBITORS | DHODH, DHFR, DPYD | DHODH 1/4885PARP1 2754/4885PSMB8 3979/4885 |
| US-11717512-B2 | Methods of use for trisubstituted benzotriazole derivatives | BRDT, BRPF3, BRD4 | DHODH 441/4885PARP1 408/4885PSMB8 3979/4885 |
| US-20160200693-A1 | Trisubstituted Benzotriazole Derivatives as Dihydroorotate Oxygenase Inhibitors | DHODH, HAAO, TALDO1 | DHODH 1/4885PARP1 2946/4885PSMB8 3481/4885 |
| US-11147801-B2 | Methods of use for trisubstituted benzotriazole derivatives as dihydroorotate oxygenase inhibitors | DHODH, DHFR, DDO | DHODH 1/4885PARP1 3282/4885PSMB8 4133/4885 |
| US-20210113531-A1 | METHODS OF USE FOR TRISUBSTITUTED BENZOTRIAZOLE DERIVATIVES | BRDT, BRPF3, BRD4 | DHODH 441/4885PARP1 408/4885PSMB8 3979/4885 |
| US-20170224663-A1 | Methods of Use for Trisubstituted Benzotriazole Derivatives as Dihydroorotate Oxygenase Inhibitors | DHODH, DHFR, DDO | DHODH 1/4885PARP1 3282/4885PSMB8 4133/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.