Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 14/20 | 0.74 |
| ▸ | RAB9A | P51151 | 10/20 | 0.66 |
| ▸ | NPC1 | O15118 | 8/20 | 0.66 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.66 |
| ▸ | MEN1 | O00255 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.66 |
| ▸ | GAA | P10253 | 1/20 | 0.66 |
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.61 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.61 |
| ▸ | RELA | Q04206 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28904594 | 0.92 | EPHX1 (0.61) | EPHX1RAB9ANPC1EPHX2SMN1; SMN2 | |
| SCHEMBL13756244 | 0.87 | EPHX1 (0.86) | EPHX1RAB9ANPC1EPHX2SMN1; SMN2 | |
| SCHEMBL13756248 | 0.85 | EPHX1 (0.83) | EPHX1RAB9ANPC1EPHX2SMN1; SMN2 | |
| SCHEMBL14506148 | 0.85 | EPHX1 (1.00) | EPHX1RAB9ANPC1EPHX2SMN1; SMN2 | |
| SCHEMBL9755532 | 0.85 | EPHX1 (1.00) | EPHX1RAB9ANPC1EPHX2SMN1; SMN2 | |
| SCHEMBL2752610 | 0.83 | EPHX1 (0.97) | EPHX1RAB9ANPC1EPHX2SMN1; SMN2 | |
| SCHEMBL5408003 | 0.83 | RAB9A (0.65) | EPHX1RAB9ANPC1EPHX2SMN1; SMN2 | |
| SCHEMBL12196184 | 0.81 | EPHX1 (1.00) | EPHX1RAB9ANPC1EPHX2SMN1; SMN2 | |
| SCHEMBL8391687 | 0.81 | EPHX1 (1.00) | EPHX1RAB9ANPC1EPHX2SMN1; SMN2 | |
| SCHEMBL17316265 | 0.80 | EPHX2 (0.56) | EPHX1EPHX2SMN1; SMN2CYP2C19MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8815951-B2 | Inhibitors of epoxide hydrolases for the treatment of inflammation | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-08-26 | — | — | US | disclosed |