Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 14/20 | 0.87 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | PI4KA | P42356 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.35 |
| ▸ | MAP3K12 | Q12852 | 3/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | CDK7 | P50613 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.33 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.33 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL532090 | 0.93 | PIK3CA (1.00) | PIK3CALRRK2PIK3CDPIK3CBPI4KA | |
| SCHEMBL15975842 | 0.80 | PIK3CA (0.86) | PIK3CAPIK3CDPIK3CBPIK3CGKIT | |
| SCHEMBL15975821 | 0.79 | PIK3CA (0.86) | PIK3CA | |
| SCHEMBL532091 | 0.77 | PIK3CA (0.71) | PIK3CALRRK2MAP3K12 | |
| SCHEMBL15975843 | 0.77 | PIK3CA (0.87) | PIK3CA | |
| SCHEMBL15975829 | 0.76 | PIK3CA (0.61) | PIK3CA | |
| SCHEMBL15975813 | 0.76 | PIK3CA (0.71) | PIK3CA | |
| SCHEMBL15975816 | 0.75 | PIK3CA (0.63) | PIK3CA | |
| SCHEMBL15975814 | 0.74 | PIK3CA (0.59) | PIK3CAKITPIM1FLT3CDK7 | |
| SCHEMBL15975841 | 0.74 | PIK3CA (0.88) | PIK3CAKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8815918-B2 | Imidazo [2, 1-B] [1, 3, 4] thiadiazole derivatives | CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO) (ES) | 2014-08-26 | — | — | US | disclosed |