Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 9/20 | 0.82 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15975830 | 0.91 | PIK3CA (0.68) | PIK3CAMAPK1ALDH1A1MAPTUSP2 | |
| SCHEMBL532183 | 0.90 | PIK3CA (1.00) | PIK3CAMAPK1LMNAALDH1A1MAPT | |
| SCHEMBL533270 | 0.81 | PIK3CA (0.83) | PIK3CAMAPK1 | |
| SCHEMBL532981 | 0.79 | PIK3CA (0.64) | PIK3CAMAPK1LMNAALDH1A1MAPT | |
| SCHEMBL532184 | 0.76 | PIK3CA (0.75) | PIK3CAMAPK1LMNAALDH1A1MAPT | |
| SCHEMBL533128 | 0.76 | PIK3CA (1.00) | PIK3CA | |
| SCHEMBL15975838 | 0.75 | PIK3CA (0.55) | PIK3CA | |
| SCHEMBL15975837 | 0.75 | PIK3CA (0.63) | PIK3CAALDH1A1HPGDHSD17B10 | |
| SCHEMBL15975841 | 0.71 | PIK3CA (0.88) | PIK3CA | |
| SCHEMBL15975832 | 0.70 | PIK3CA (0.59) | PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8815918-B2 | Imidazo [2, 1-B] [1, 3, 4] thiadiazole derivatives | CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO) (ES) | 2014-08-26 | — | — | US | disclosed |