Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 13/20 | 0.48 |
| ▸ | PGR | P06401 | 2/20 | 0.35 |
| ▸ | ALPL | P05186 | 1/20 | 0.34 |
| ▸ | ALPI | P09923 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL531960 | 0.90 | PIK3CA (0.56) | PIK3CAPGR | |
| SCHEMBL2124315 | 0.78 | PIK3CA (0.53) | PIK3CAPIK3CD | |
| SCHEMBL2122854 | 0.77 | PIK3CA (0.42) | PIK3CAPIK3CD | |
| SCHEMBL15975840 | 0.75 | PIK3CA (0.47) | PIK3CAPIK3CD | |
| SCHEMBL15975832 | 0.73 | PIK3CA (0.59) | PIK3CA | |
| SCHEMBL15975827 | 0.72 | PIK3CA (0.79) | PIK3CA | |
| SCHEMBL15975838 | 0.71 | PIK3CA (0.55) | PIK3CAALPLALPI | |
| SCHEMBL15975837 | 0.70 | PIK3CA (0.63) | PIK3CA | |
| SCHEMBL532219 | 0.68 | PIK3CA (0.82) | PIK3CA | |
| SCHEMBL15975830 | 0.68 | PIK3CA (0.68) | PIK3CAMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8815918-B2 | Imidazo [2, 1-B] [1, 3, 4] thiadiazole derivatives | CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO) (ES) | 2014-08-26 | — | — | US | disclosed |