Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 13/20 | 0.47 |
| ▸ | MET | P08581 | 2/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2124315 | 0.96 | PIK3CA (0.53) | PIK3CAMETPIK3CDROCK2SYK | |
| SCHEMBL2124319 | 0.84 | PIK3CA (0.38) | PIK3CAMETPIK3CDSYK | |
| SCHEMBL532360 | 0.84 | PIK3CD (0.38) | PIK3CDROCK2PARP1 | |
| SCHEMBL531960 | 0.81 | PIK3CA (0.56) | PIK3CAMET | |
| SCHEMBL15975833 | 0.75 | PIK3CA (0.48) | PIK3CAPIK3CD | |
| SCHEMBL532361 | 0.74 | PIK3CD (0.38) | PIK3CDPARP1 | |
| SCHEMBL532710 | 0.73 | PIK3CA (0.58) | PIK3CAPIK3CD | |
| SCHEMBL627431 | 0.73 | PIK3CA (0.48) | PIK3CA | |
| SCHEMBL627019 | 0.72 | PIK3CA (0.47) | PIK3CAHDAC1HDAC2 | |
| SCHEMBL15975821 | 0.72 | PIK3CA (0.86) | PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8815918-B2 | Imidazo [2, 1-B] [1, 3, 4] thiadiazole derivatives | CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO) (ES) | 2014-08-26 | — | — | US | disclosed |