Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 7/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KLK7 | P49862 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 6/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ALPL | P05186 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15800322 | 0.90 | PLA2G2A (0.47) | PLA2G2AKDM4ECYP1A2CYP2D6CYP2C9 | |
| SCHEMBL15800320 | 0.90 | PLA2G2A (0.54) | PLA2G2AKDM4ECYP1A2CYP2D6CYP2C9 | |
| SCHEMBL15976003 | 0.88 | PLA2G2A (0.50) | PLA2G2AKDM4ECYP1A2CYP2D6CYP2C9 | |
| SCHEMBL15976007 | 0.86 | PLA2G2A (0.50) | PLA2G2AKDM4ECYP1A2CYP2D6CYP2C9 | |
| SCHEMBL108830 | 0.81 | PLA2G2A (0.55) | PLA2G2AKDM4ECYP1A2CYP2D6CYP2C9 | |
| SCHEMBL15976006 | 0.81 | PLA2G2A (0.48) | PLA2G2AKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL15976010 | 0.74 | DHODH (0.41) | PLA2G2AKDM4EMAPTNPC1RAB9A | |
| SCHEMBL15976449 | 0.72 | DHODH (0.41) | PLA2G2AKDM4EMAPTNPC1RAB9A | |
| SCHEMBL141016 | 0.71 | PLA2G2A (0.55) | PLA2G2AKDM4ECYP1A2CYP2D6CYP2C9 | |
| SCHEMBL15800340 | 0.69 | KDM4E (0.43) | KDM4EMAPTSMN1; SMN2LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8815840-B2 | Carbazole and carboline kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2014-08-26 | — | — | US | disclosed |
| US-20120058988-A1 | CARBAZOLE AND CARBOLINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2012-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120058988-A1 | CARBAZOLE AND CARBOLINE KINASE INHIBITORS | JAK2, JAK1, JAK3 | PLA2G2A 4509/4885KDM4E 928/4885CYP1A2 1040/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.