Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | NCF1 | P14598 | 7/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 4/20 | 0.35 |
| ▸ | CYBB | P04839 | 1/20 | 0.34 |
| ▸ | NOX5 | Q96PH1 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.34 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.34 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15976247 | 0.91 | GBA1 (0.47) | GBA1DPP4NCF1MEN1KMT2A | |
| SCHEMBL15976246 | 0.91 | GBA1 (0.47) | GBA1DPP4NCF1MEN1KMT2A | |
| SCHEMBL15281111 | 0.86 | CHRNA7 (0.38) | DPP4NCF1CHRNA7DRD2DRD4 | |
| SCHEMBL18850692 | 0.86 | CHRNA7 (0.38) | DPP4NCF1CHRNA7DRD2DRD4 | |
| SCHEMBL17586038 | 0.86 | CHRNA7 (0.38) | DPP4NCF1CHRNA7DRD2DRD4 | |
| SCHEMBL15223677 | 0.86 | CHRNA7 (0.38) | DPP4NCF1CHRNA7DRD2DRD4 | |
| SCHEMBL22564941 | 0.85 | GBA1 (0.34) | GBA1DPP4CHRNA7MAPT | |
| SCHEMBL24029526 | 0.84 | MAPK14 (0.45) | DPP4NCF1CHRNA7DRD2CYBB | |
| SCHEMBL20047038 | 0.84 | MAPK14 (0.45) | DPP4NCF1CHRNA7DRD2CYBB | |
| SCHEMBL25819728 | 0.83 | DPP4 (0.35) | GBA1DPP4NCF1CHRNA7DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8815927-B2 | Bivalent diazo bicyclic Smac mimetics and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2014-08-26 | — | — | US | disclosed |