Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 12/20 | 0.51 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.51 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.51 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 2/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.36 |
| ▸ | CFTR | P13569 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL532071 | 0.92 | PIK3CA (0.55) | PIK3CAPIK3CDPIK3CBPIK3CGMAPT | |
| SCHEMBL3512900 | 0.86 | PIK3CA (0.71) | PIK3CAPIK3CDPIK3CBPIK3CGATM | |
| SCHEMBL532283 | 0.85 | PIK3CA (0.67) | PIK3CAPIK3CDPIK3CBPIK3CGMAPT | |
| SCHEMBL3513424 | 0.84 | PIK3CA (0.70) | PIK3CAPIK3CDPIK3CBPIK3CGATM | |
| SCHEMBL532165 | 0.83 | PIK3CA (0.55) | PIK3CAPIK3CDPIK3CBPIK3CGMAPT | |
| SCHEMBL532072 | 0.82 | PIK3CA (0.53) | PIK3CAPIK3CDPIK3CBPIK3CGMAPT | |
| SCHEMBL12988788 | 0.81 | PIK3CA (0.70) | PIK3CAPIK3CDPIK3CBPIK3CGATM | |
| SCHEMBL532397 | 0.81 | PIK3CA (0.57) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL15975808 | 0.81 | PIK3CA (0.66) | PIK3CAPIK3CDPIK3CBPIK3CGLMNA | |
| SCHEMBL533077 | 0.80 | PIK3CA (0.53) | PIK3CAPIK3CDPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2414369-B1 | IMIDAZO[2,1-B][1,3,4]THIADIAZOLE DERIVATIVES | FUNDACIÓN CT NAC DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (ES) | 2015-08-12 | — | — | EP | disclosed |
| US-8815918-B2 | Imidazo [2, 1-B] [1, 3, 4] thiadiazole derivatives | CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO) (ES) | 2014-08-26 | — | — | US | disclosed |