SCHEMBL15977327

SCHEMBL15977327

CC1=C(C)C(=O)N(CC(C)C)C1=O

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.41
PKM P14618 1/20 0.41
GAA P10253 1/20 0.38
EP300 Q09472 2/20 0.37
MPO P05164 1/20 0.37
MEN1 O00255 2/20 0.36
KMT2A Q03164 2/20 0.36
PIK3CD O00329 3/20 0.35
L3MBTL1 Q9Y468 2/20 0.34
SMN1; SMN2 Q16637 2/20 0.34
TSHR P16473 1/20 0.34
HSD17B10 Q99714 1/20 0.34
TDP1 Q9NUW8 1/20 0.34
TOP2A P11388 1/20 0.34
NPC1 O15118 2/20 0.34
RAB9A P51151 2/20 0.34
KDM4E B2RXH2 1/20 0.33
MAPT P10636 1/20 0.33
THRB P10828 1/20 0.33
BRD4 O60885 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10785350 0.80 ALDH1A1 (0.43) ALDH1A1PKMKMT2ASMN1; SMN2KDM4E
SCHEMBL23665440 0.77 EP300 (0.40) ALDH1A1GAAEP300MPOMEN1
SCHEMBL8283005 0.75 ALDH1A1 (0.38) ALDH1A1GAAEP300MPOMEN1
SCHEMBL23665372 0.75 GAA (0.33) ALDH1A1GAAEP300MPOMEN1
SCHEMBL24939867 0.75 ALDH1A1 (0.48) ALDH1A1PKMPOLBLMNA
SCHEMBL16658928 0.75 F2 (0.45) ALDH1A1GAAEP300MPOPIK3CD
SCHEMBL5663770 0.73 ALDH1A1 (0.38) ALDH1A1PKMKDM4ELMNA
SCHEMBL10951983 0.72 ALDH1A1 (0.44) ALDH1A1PKMPOLB
SCHEMBL14377608 0.72 ALDH1A1 (0.41) ALDH1A1PKMMEN1KMT2ASMN1; SMN2
SCHEMBL10935097 0.72 CA9 (0.38) GAAEP300MPOPIK3CDTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170247725-A1 IN VIVO AND IN VITRO OLEFIN CYCLOPROPANATION CATALYZED BY HEME ENZYMES CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2017-08-31 US disclosed
US-9493799-B2 In vivo and in vitro olefin cyclopropanation catalyzed by heme enzymes CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2016-11-15 US disclosed
US-20160032330-A1 P-450-CATALYZED ENANTIOSELECTIVE CYCLOPROPANATION OF ELECTRON-DEFICIENT OLEFINS CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2016-02-04 US disclosed
US-20160002682-A1 IN VIVO AND IN VITRO OLEFIN CYCLOPROPANATION CATALYZED BY HEME ENZYMES UNITED STATES DEPARTMENT OF ENERGY 2016-01-07 US disclosed
US-8993262-B2 In vivo and in vitro olefin cyclopropanation catalyzed by heme enzymes CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2015-03-31 US disclosed
US-20140242647-A1 IN VIVO AND IN VITRO OLEFIN CYCLOPROPANATION CATALYZED BY HEME ENZYMES CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2014-08-28 US disclosed
CN-102382028-A Maleimide compound, its preparation and application UNIV ZHEJIANG TECHNOLOGY 2012-03-21 CN disclosed