SCHEMBL15977375

SCHEMBL15977375

CC1([Si](C)(C)C)CC1N1C(=O)c2ccccc2C1=O

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.41
DDB1 Q16531 2/20 0.41
CRBN Q96SW2 2/20 0.41
TSHR P16473 2/20 0.41
ALDH1A1 P00352 2/20 0.41
CHRM2 P08172 1/20 0.41
OPRM1 P35372 1/20 0.41
IKZF3 Q9UKT9 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
ACHE P22303 1/20 0.39
CYP2C9 P11712 1/20 0.36
CYP2C19 P33261 1/20 0.36
MAPT P10636 1/20 0.35
RECQL P46063 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
CASP3 P42574 1/20 0.34
LMNA P02545 1/20 0.33
CRHBP P24387 1/20 0.33
CRHR2 Q13324 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15977374 0.80 ALDH1A1 (0.46) CYP1A2DDB1CRBNTSHRALDH1A1
SCHEMBL24718407 0.69 ALDH1A1 (0.43) CYP1A2DDB1CRBNTSHRALDH1A1
SCHEMBL21121209 0.69 DDB1 (0.46) CYP1A2DDB1CRBNTSHRALDH1A1
SCHEMBL24718408 0.69 ALDH1A1 (0.43) CYP1A2DDB1CRBNTSHRALDH1A1
SCHEMBL21121207 0.69 DDB1 (0.46) CYP1A2DDB1CRBNTSHRALDH1A1
SCHEMBL20746470 0.68 TSHR (0.41) CYP1A2DDB1CRBNTSHRALDH1A1
SCHEMBL13297938 0.68 TSHR (0.41) CYP1A2DDB1CRBNTSHRALDH1A1
SCHEMBL3048785 0.68 ALDH1A1 (0.45) CYP1A2DDB1CRBNTSHRALDH1A1
SCHEMBL15200389 0.67 TSHR (0.41) CYP1A2DDB1CRBNTSHRALDH1A1
SCHEMBL22124773 0.66 CYP2C19 (0.38) CYP1A2DDB1CRBNTSHRALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170247725-A1 IN VIVO AND IN VITRO OLEFIN CYCLOPROPANATION CATALYZED BY HEME ENZYMES CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2017-08-31 US disclosed
US-9493799-B2 In vivo and in vitro olefin cyclopropanation catalyzed by heme enzymes CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2016-11-15 US disclosed
US-20160032330-A1 P-450-CATALYZED ENANTIOSELECTIVE CYCLOPROPANATION OF ELECTRON-DEFICIENT OLEFINS CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2016-02-04 US disclosed
US-20160002682-A1 IN VIVO AND IN VITRO OLEFIN CYCLOPROPANATION CATALYZED BY HEME ENZYMES UNITED STATES DEPARTMENT OF ENERGY 2016-01-07 US disclosed
US-8993262-B2 In vivo and in vitro olefin cyclopropanation catalyzed by heme enzymes CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2015-03-31 US disclosed
US-20140242647-A1 IN VIVO AND IN VITRO OLEFIN CYCLOPROPANATION CATALYZED BY HEME ENZYMES CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2014-08-28 US disclosed