Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL806751 | 0.94 | KDM4E (0.33) | IMPDH2L3MBTL1MAPK1KDM4ELMNA | |
| SCHEMBL15978362 | 0.82 | APP (0.42) | MAPK1LMNA | |
| SCHEMBL806720 | 0.81 | HTR2A (0.34) | IMPDH2 | |
| SCHEMBL806744 | 0.80 | KDM4E (0.38) | IMPDH2L3MBTL1MAPK1KDM4E | |
| SCHEMBL806903 | 0.75 | BACE1 (0.42) | MAPK1LMNA | |
| SCHEMBL15978363 | 0.72 | CNR2 (0.34) | L3MBTL1MAPK1KDM4ELMNA | |
| SCHEMBL15978280 | 0.70 | IMPDH2 (0.35) | IMPDH2 | |
| SCHEMBL806897 | 0.69 | CYP3A4 (0.38) | KDM4E | |
| SCHEMBL806745 | 0.66 | IMPDH2 (0.34) | IMPDH2LMNA | |
| SCHEMBL15978364 | 0.65 | APP (0.44) | IMPDH2MAPK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140243404-A1 | UNIQUE HALOGEN-INDUCED CYCLIZATIONS, REAGENTS THEREFOR, AND COMPOUNDS PRODUCED THEREBY | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2014-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140243404-A1 | UNIQUE HALOGEN-INDUCED CYCLIZATIONS, REAGENTS THEREFOR, AND COMPOUNDS PRODUCED THEREBY | WEE1, WEE2, NOTUM | IMPDH2 2395/4885L3MBTL1 518/4885MAPK1 2458/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.