Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 6/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.44 |
| ▸ | PIM1 | P11309 | 4/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.44 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.44 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.44 |
| ▸ | LTK | P29376 | 1/20 | 0.43 |
| ▸ | MST1R | Q04912 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 13/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.42 |
| ▸ | TAOK1 | Q7L7X3 | 5/20 | 0.42 |
| ▸ | HIPK4 | Q8NE63 | 5/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.42 |
| ▸ | PLK4 | O00444 | 4/20 | 0.42 |
| ▸ | FLT4 | P35916 | 4/20 | 0.42 |
| ▸ | FLT3 | P36888 | 4/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15984818 | 0.83 | ROCK1 (0.49) | ROCK1CLK4PIM1DYRK1ACDK5 | |
| SCHEMBL30190467 | 0.77 | CLK4 (0.51) | ROCK1CLK4PIM1DYRK1ACDK5 | |
| SCHEMBL15980671 | 0.75 | GSK3B (0.51) | ROCK1CLK4PIM1DYRK1BFLT3 | |
| SCHEMBL28860690 | 0.74 | CLK4 (0.51) | ROCK1CLK4PIM1DYRK1ACDK5 | |
| SCHEMBL15980672 | 0.74 | CLK4 (0.51) | ROCK1CLK4PIM1LRRK2DYRK1B | |
| SCHEMBL25737805 | 0.73 | MKNK2 (0.42) | ROCK1CLK4PIM1DYRK1ACDK5 | |
| SCHEMBL16135656 | 0.72 | KDR (0.40) | ROCK1CLK4PIM1DYRK1ACDK5 | |
| SCHEMBL30775244 | 0.71 | PARP10 (0.57) | ROCK1CLK4PIM1DYRK1ACDK5 | |
| SCHEMBL9910069 | 0.71 | CLK4 (0.56) | ROCK1CLK4PIM1DYRK1ACDK5 | |
| SCHEMBL28860691 | 0.70 | KDR (0.54) | ROCK1CLK4PIM1DYRK1ACDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9216173-B2 | 2-Pyridyl carboxamide-containing spleen tyrosine kinase (SYK) inhibitors | MERCK SHARP & DOHME CORP. (US) | 2015-12-22 | — | — | US | disclosed |
| US-20140243336-A1 | 2-Pyridyl Carboxamide-Containing Spleen Tyrosine Kinase (SYK) Inhibitors | MERCK SHARP & DOHME LLC | 2014-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140243336-A1 | 2-Pyridyl Carboxamide-Containing Spleen Tyrosine Kinase (SYK) Inhibitors | SYK, BTK, LCK | ROCK1 545/4885CLK4 1101/4885PIM1 256/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.