Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.51 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.51 |
| ▸ | PIM1 | P11309 | 1/20 | 0.51 |
| ▸ | FLT3 | P36888 | 1/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.51 |
| ▸ | BRAF | P15056 | 1/20 | 0.46 |
| ▸ | PRKCI | P41743 | 1/20 | 0.46 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.45 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.45 |
| ▸ | TARS1 | P26639 | 1/20 | 0.44 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.42 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.41 |
| ▸ | PRF1 | P14222 | 3/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | F9 | P00740 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15980672 | 0.91 | CLK4 (0.51) | GSK3BCLK4DAPK3NTRK1PIM1 | |
| SCHEMBL15984853 | 0.83 | GSK3B (0.56) | GSK3BCLK4DAPK3NTRK1PIM1 | |
| SCHEMBL15730875 | 0.77 | CLK4 (0.58) | GSK3BCLK4DAPK3NTRK1PIM1 | |
| SCHEMBL23502017 | 0.75 | PRKCI (0.50) | GSK3BCLK4DAPK3NTRK1PIM1 | |
| SCHEMBL15980666 | 0.75 | ROCK1 (0.44) | GSK3BCLK4NTRK1PIM1FLT3 | |
| SCHEMBL15984816 | 0.74 | CLK4 (0.56) | GSK3BCLK4DAPK3NTRK1PIM1 | |
| SCHEMBL16135652 | 0.73 | CLK4 (0.55) | GSK3BCLK4DAPK3NTRK1PIM1 | |
| SCHEMBL25737805 | 0.72 | MKNK2 (0.42) | GSK3BCLK4DAPK3NTRK1PIM1 | |
| SCHEMBL279725 | 0.70 | CLK4 (0.49) | GSK3BCLK4DAPK3NTRK1PIM1 | |
| SCHEMBL13680577 | 0.70 | CLK4 (0.53) | GSK3BCLK4DAPK3NTRK1PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9216173-B2 | 2-Pyridyl carboxamide-containing spleen tyrosine kinase (SYK) inhibitors | MERCK SHARP & DOHME CORP. (US) | 2015-12-22 | — | — | US | disclosed |
| US-20140243336-A1 | 2-Pyridyl Carboxamide-Containing Spleen Tyrosine Kinase (SYK) Inhibitors | MERCK SHARP & DOHME LLC | 2014-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140243336-A1 | 2-Pyridyl Carboxamide-Containing Spleen Tyrosine Kinase (SYK) Inhibitors | SYK, BTK, LCK | GSK3B 374/4885CLK4 1101/4885DAPK3 161/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.