Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 1/20 | 0.55 |
| ▸ | CDK4 | P11802 | 1/20 | 0.50 |
| ▸ | CCND1 | P24385 | 1/20 | 0.50 |
| ▸ | CCND2 | P30279 | 1/20 | 0.50 |
| ▸ | CCND3 | P30281 | 1/20 | 0.50 |
| ▸ | SYK | P43405 | 4/20 | 0.43 |
| ▸ | EGFR | P00533 | 6/20 | 0.43 |
| ▸ | BTK | Q06187 | 5/20 | 0.43 |
| ▸ | ITK | Q08881 | 3/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | LYN | P07948 | 1/20 | 0.43 |
| ▸ | TEC | P42680 | 1/20 | 0.43 |
| ▸ | TXK | P42681 | 1/20 | 0.43 |
| ▸ | BMX | P51813 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | CD69 | Q07108 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17409829 | 0.83 | BRAF (0.55) | BRAFCDK4CCND1CCND2CCND3 | |
| SCHEMBL29575809 | 0.79 | BRAF (0.65) | BRAFCDK4CCND1CCND2CCND3 | |
| SCHEMBL15987162 | 0.78 | BRAF (0.47) | BRAFCDK4CCND1CCND2CCND3 | |
| SCHEMBL23409127 | 0.76 | BRAF (0.53) | BRAFCDK4CCND1CCND2CCND3 | |
| SCHEMBL17388690 | 0.75 | BRAF (0.47) | BRAFCDK4CCND1CCND2CCND3 | |
| SCHEMBL3040980 | 0.75 | BRAF (0.69) | BRAFCDK4CCND1CCND2CCND3 | |
| SCHEMBL19533535 | 0.74 | BRAF (0.54) | BRAFCDK4CCND1CCND2CCND3 | |
| SCHEMBL19544927 | 0.73 | SYK (0.57) | BRAFCDK4CCND1CCND2CCND3 | |
| SCHEMBL31688432 | 0.73 | BRAF (0.52) | BRAFCDK4CCND1CCND2CCND3 | |
| SCHEMBL19533540 | 0.73 | BRAF (0.45) | BRAFCDK4CCND1CCND2CCND3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9708326-B2 | Inhibitors of bruton's tyrosine kinase | PHARMACYCLICS LLC (US) | 2017-07-18 | — | — | US | disclosed |
| US-20160002241-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS, LLC. (US) | 2016-01-07 | — | — | US | disclosed |
| WO-2014130693-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS, INC. (US) | 2014-08-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160002241-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | BTK, LYN, LCK | BRAF 107/4885CDK4 375/4885CCND1 2725/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.