Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 4/20 | 0.44 |
| ▸ | PARP1 | P09874 | 15/20 | 0.44 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.44 |
| ▸ | FNTA | P49354 | 1/20 | 0.40 |
| ▸ | FNTB | P49356 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3082595 | 0.94 | PARP1 (0.51) | PARP1PARP2 | |
| SCHEMBL3068742 | 0.93 | PARP1 (0.41) | P2RX7PARP1PARP2 | |
| SCHEMBL3075336 | 0.93 | PARP1 (0.43) | P2RX7PARP1PARP2 | |
| SCHEMBL3080604 | 0.92 | PARP1 (0.42) | PARP1PARP2 | |
| SCHEMBL3085639 | 0.91 | PARP1 (0.42) | PARP1PARP2 | |
| SCHEMBL3075500 | 0.91 | PARP1 (0.44) | P2RX7PARP1PARP2 | |
| SCHEMBL3075470 | 0.89 | P2RX7 (0.46) | P2RX7PARP1PARP2 | |
| SCHEMBL3069574 | 0.87 | P2RX7 (0.50) | P2RX7 | |
| SCHEMBL3081577 | 0.86 | P2RX7 (0.43) | P2RX7PARP1PARP2 | |
| SCHEMBL3080936 | 0.84 | PARP1 (0.51) | P2RX7PARP1PARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2220073-B1 | PYRIDAZINONE DERIVATIVES AS PARP INHIBITORS | MSD ITALIA SRL (IT) | 2014-09-03 | — | — | EP | disclosed |