Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16000804 | 0.86 | MAPK14 (0.40) | NOTUMLRRK2KMT2AALOX12NPC1 | |
| SCHEMBL19416842 | 0.84 | NOTUM (0.51) | NOTUMKMT2AALOX12NPC1MAPT | |
| SCHEMBL13860583 | 0.78 | NOTUM (0.43) | NOTUMKMT2ANPC1MAPTRAB9A | |
| SCHEMBL16000807 | 0.77 | NOTUM (0.44) | NOTUMNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL16675212 | 0.77 | ALDH1A1 (0.49) | NOTUMLRRK2KMT2AALOX12NPC1 | |
| SCHEMBL14438048 | 0.76 | KMT2A (0.62) | NOTUMKMT2AALOX12NPC1MAPT | |
| SCHEMBL15992883 | 0.76 | NOTUM (0.37) | NOTUMKMT2AALOX12NPC1MAPT | |
| SCHEMBL4001854 | 0.75 | ALDH1A1 (0.40) | KDM4EL3MBTL1ALDH1A1LMNAPOLB | |
| SCHEMBL16000799 | 0.75 | NOTUM (0.55) | NOTUMKMT2AALOX12NPC1MAPT | |
| SCHEMBL16000821 | 0.75 | NOTUM (0.43) | NOTUMLRRK2KMT2ANPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9156830-B2 | Heterocyclic compounds | SHIONOGI & CO., LTD. (JP) | 2015-10-13 | — | — | US | disclosed |
| US-20140249159-A1 | HETEROCYCLIC COMPOUNDS | PURDUE PHARMA L.P. | 2014-09-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140249159-A1 | HETEROCYCLIC COMPOUNDS | HRH2, UGT1A3, UGT1A1 | NOTUM 4629/4885LRRK2 658/4885KMT2A 3048/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.