Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 20/20 | 1.00 |
| ▸ | HDAC1 | Q13547 | 5/20 | 1.00 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 1.00 |
| ▸ | HDAC2 | Q92769 | 4/20 | 1.00 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.80 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.80 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.75 |
| ▸ | PDE2A | O00408 | 1/20 | 0.75 |
| ▸ | ABCC5 | O15440 | 1/20 | 0.75 |
| ▸ | PDE6D | O43924 | 1/20 | 0.75 |
| ▸ | PDE8A | O60658 | 1/20 | 0.75 |
| ▸ | PDE9A | O76083 | 1/20 | 0.75 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.75 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.75 |
| ▸ | HTR1A | P08908 | 1/20 | 0.75 |
| ▸ | PDE6A | P16499 | 1/20 | 0.75 |
| ▸ | PDE6G | P18545 | 1/20 | 0.75 |
| ▸ | PDE4A | P27815 | 1/20 | 0.75 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.75 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16003915 | 0.96 | PDE5A (1.00) | PDE5AHDAC1HDAC6HDAC2PDE3B | |
| SCHEMBL17390175 | 0.90 | PDE5A (0.85) | PDE5AHDAC1HDAC6HDAC2PDE3B | |
| SCHEMBL17404874 | 0.89 | PDE5A (1.00) | PDE5AHDAC1HDAC6HDAC2PDE3B | |
| Lodenafil SCHEMBL31202790 | 0.89 | PDE5A (1.00) | PDE5AHDAC1HDAC6HDAC2PDE3B | |
| Lodenafil SCHEMBL1058 | 0.89 | PDE5A (1.00) | PDE5AHDAC1HDAC6HDAC2PDE3B | |
| SCHEMBL30848678 | 0.89 | PDE5A (0.95) | PDE5AHDAC1HDAC6HDAC2PDE3B | |
| SCHEMBL17390250 | 0.88 | PDE5A (0.83) | PDE5AHDAC1HDAC6HDAC2PDE3B | |
| SCHEMBL5010426 | 0.88 | PDE5A (0.90) | PDE5AHDAC1HDAC6HDAC2PDE3B | |
| SCHEMBL17342850 | 0.88 | PDE5A (1.00) | PDE5AHDAC1HDAC6HDAC2PDE3B | |
| SCHEMBL29358004 | 0.88 | PDE5A (1.00) | PDE5AHDAC1HDAC6HDAC2PDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2961741-B1 | NOVEL COMPOUNDS AS DUAL INHIBITORS OF PHOSPHODIESTERASES AND HISTONE DEACETYLASES | FUND PARA LA INVESTIG MEDICA APLICADA (ES) | 2017-04-05 | — | — | EP | disclosed |
| US-9573956-B2 | Compounds as dual inhibitors of phosphodiesterases and histone deacetylases | FUNDACIÓN PARA LA INVESTIGACIÓN MÉDICA APLICADA (ES) | 2017-02-21 | — | — | US | disclosed |
| US-9573956-B2 | Compounds as dual inhibitors of phosphodiesterases and histone deacetylases | FUNDACIÓN PARA LA INVESTIGACIÓN MÉDICA APLICADA (ES) | 2017-02-21 | — | — | US | disclosed |
| US-20160002246-A1 | NOVEL COMPOUNDS AS DUAL INHIBITORS OF PHOSPHODIESTERASES AND HISTONE DEACETYLASES | FUNDACIÓN PARA LA INVESTIGACIÓN MÉDICA APLICADA (ES) | 2016-01-07 | — | — | US | disclosed |
| US-20160002246-A1 | NOVEL COMPOUNDS AS DUAL INHIBITORS OF PHOSPHODIESTERASES AND HISTONE DEACETYLASES | FUNDACIÓN PARA LA INVESTIGACIÓN MÉDICA APLICADA (ES) | 2016-01-07 | — | — | US | disclosed |
| WO-2014131855-A1 | NOVEL COMPOUNDS AS DUAL INHIBITORS OF PHOSPHODIESTERASES AND HISTONE DEACETYLASES | FUNDACIÓN PARA LA INVESTIGACIÓN MÉDICA APLICADA (ES) | 2014-09-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160002246-A1 | NOVEL COMPOUNDS AS DUAL INHIBITORS OF PHOSPHODIESTERASES AND HISTONE DEACETYLASES | PDE1A, HDAC1, HDAC2 | PDE5A 24/4885HDAC1 2/4885HDAC6 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.