Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR142 | Q7Z601 | 10/20 | 0.53 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.50 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.50 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.50 |
| ▸ | EEF2K | O00418 | 1/20 | 0.42 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16004314 | 0.90 | GPR142 (0.56) | GPR142NPC1RAB9A | |
| SCHEMBL16004105 | 0.88 | GPR142 (0.55) | GPR142 | |
| SCHEMBL16004309 | 0.82 | NPC1 (0.43) | GPR142POLBNPC1RAB9AALDH1A1 | |
| SCHEMBL16004157 | 0.80 | GPR142 (0.58) | GPR142 | |
| SCHEMBL16004312 | 0.80 | NPC1 (0.46) | GPR142POLBNPC1RAB9AKMT2A | |
| SCHEMBL16004094 | 0.79 | GPR142 (0.64) | GPR142 | |
| SCHEMBL16004087 | 0.78 | MAPT (0.53) | GPR142RIPK1POLBALDH1A1KMT2A | |
| SCHEMBL16004319 | 0.78 | GPR142 (0.60) | GPR142POLBALDH1A1PKM | |
| SCHEMBL16004093 | 0.77 | GPR142 (0.54) | GPR142TAS1R3TAS1R1TAS1R2POLB | |
| SCHEMBL16004092 | 0.76 | GPR142 (0.53) | GPR142RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014133414-A2 | HETEROCYCLIC TGR5 BILE ACID RECEPTOR AGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR THE PRODUCTION AND USE THEREOF | АЛЛА ХЕМ ЛЛС (US) | 2014-09-04 | — | — | WO | disclosed |