Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.38 |
| ▸ | GHSR | Q92847 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 2/20 | 0.36 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29501163 | 0.84 | HCRTR2 (0.43) | USP30ATMSCD5GPR119MEN1 | |
| SCHEMBL17958021 | 0.84 | HCRTR2 (0.43) | USP30ATMSCD5GPR119MEN1 | |
| SCHEMBL30878572 | 0.81 | GHSR (0.46) | GHSRNPC1RAB9AKMT2ALMNA | |
| SCHEMBL5776208 | 0.81 | GHSR (0.46) | GHSRNPC1RAB9AKMT2ALMNA | |
| SCHEMBL17973702 | 0.79 | DRD3 (0.41) | ATMALDH1A1KDM4ENPC1HPGD | |
| SCHEMBL17973703 | 0.79 | DRD3 (0.41) | ATMALDH1A1KDM4ENPC1HPGD | |
| SCHEMBL18616603 | 0.78 | GHSR (0.50) | GHSRNR1H2 | |
| SCHEMBL2878054 | 0.78 | EGFR (0.45) | USP30ALDH1A1HSD17B10TDP1KMT2A | |
| SCHEMBL30418523 | 0.78 | EGFR (0.45) | USP30ALDH1A1HSD17B10TDP1KMT2A | |
| SCHEMBL17958028 | 0.77 | USP30 (0.40) | USP30ATMSCD5MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014133414-A2 | HETEROCYCLIC TGR5 BILE ACID RECEPTOR AGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR THE PRODUCTION AND USE THEREOF | АЛЛА ХЕМ ЛЛС (US) | 2014-09-04 | — | — | WO | disclosed |