Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | PREP | P48147 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31148566 | 1.00 | HPGD (0.46) | HPGDEPHX1HSD17B10PREPSMN1; SMN2 | |
| SCHEMBL31148623 | 0.98 | HSD17B10 (0.44) | HPGDEPHX1HSD17B10PREPSMN1; SMN2 | |
| SCHEMBL17770867 | 0.98 | HSD17B10 (0.44) | HPGDEPHX1HSD17B10PREPSMN1; SMN2 | |
| SCHEMBL2689039 | 0.98 | HSD17B10 (0.44) | HPGDEPHX1HSD17B10PREPSMN1; SMN2 | |
| SCHEMBL3563098 | 0.94 | HSD17B10 (0.48) | HPGDEPHX1HSD17B10SMN1; SMN2NPC1 | |
| SCHEMBL3595877 | 0.94 | HSD17B10 (0.48) | HPGDEPHX1HSD17B10SMN1; SMN2NPC1 | |
| SCHEMBL5848791 | 0.94 | HSD17B10 (0.48) | HPGDEPHX1HSD17B10SMN1; SMN2NPC1 | |
| SCHEMBL24757382 | 0.87 | HSD17B10 (0.40) | HPGDEPHX1HSD17B10PREPSMN1; SMN2 | |
| SCHEMBL22251831 | 0.87 | HSD17B10 (0.40) | HPGDEPHX1HSD17B10PREPSMN1; SMN2 | |
| SCHEMBL14398395 | 0.86 | HPGD (0.47) | HPGDEPHX1HSD17B10PREPSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240383922-A1 | KRAS Modulating Compounds | GILEAD SCIENCES, INC. | 2024-11-21 | — | — | US | disclosed |
| US-9724682-B2 | Synthesis of acyclic and cyclic amines using iron-catalyzed nitrene group transfer | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2017-08-08 | — | — | US | disclosed |
| US-20170072390-A1 | SYNTHESIS OF ACYCLIC AND CYCLIC AMINES USING IRON-CATALYZED NITRENE GROUP TRANSFER | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2017-03-16 | — | — | US | disclosed |
| US-9487472-B2 | Synthesis of acyclic and cyclic amines using iron-catalyzed nitrene group transfer | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2016-11-08 | — | — | US | disclosed |
| US-20160002145-A1 | SYNTHESIS OF ACYCLIC AND CYCLIC AMINES USING IRON-CATALYZED NITRENE GROUP TRANSFER | PRESIDENT AND FELLOWS OF HARVARD (US) | 2016-01-07 | — | — | US | disclosed |
| WO-2014134141-A1 | SYNTHESIS OF ACYCLIC AND CYCLIC AMINES USING IRON-CATALYZED NITRENE GROUP TRANSFER | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2014-09-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240383922-A1 | KRAS Modulating Compounds | KRAS, NRAS, HRAS | HPGD 2436/4885EPHX1 3345/4885HSD17B10 4557/4885 |
| US-20170072390-A1 | SYNTHESIS OF ACYCLIC AND CYCLIC AMINES USING IRON-CATALYZED NITRENE GROUP TRANSFER | FTH1, FLI1, FECH | HPGD 1357/4885EPHX1 2674/4885HSD17B10 3335/4885 |
| US-20160002145-A1 | SYNTHESIS OF ACYCLIC AND CYCLIC AMINES USING IRON-CATALYZED NITRENE GROUP TRANSFER | FTH1, FLI1, FECH | HPGD 1357/4885EPHX1 2674/4885HSD17B10 3335/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.