Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 2/20 | 0.38 |
| ▸ | PGK1 | P00558 | 4/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23654214 | 0.85 | — | — | |
| SCHEMBL16006486 | 0.84 | CRHR1 (0.39) | CRHR1PGK1GSK3BMAP4K2KDM4E | |
| SCHEMBL17761168 | 0.83 | PDE2A (0.30) | — | |
| SCHEMBL16158001 | 0.82 | CRHR1 (0.36) | CRHR1PGK1GSK3BMAP4K2KDM4E | |
| SCHEMBL19788773 | 0.80 | CRHR1 (0.34) | CRHR1PGK1 | |
| SCHEMBL20430360 | 0.80 | CYP3A4 (0.40) | KDM4E | |
| SCHEMBL20430136 | 0.77 | CCR4 (0.35) | — | |
| SCHEMBL17761167 | 0.73 | — | — | |
| SCHEMBL23653934 | 0.73 | CNR2 (0.33) | KDM4E | |
| SCHEMBL16006444 | 0.69 | MAPT (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014134566-A2 | THERAPEUTIC COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2014-09-04 | — | — | WO | disclosed |