Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4A | O75164 | 1/20 | 0.34 |
| ▸ | KDM4B | O94953 | 1/20 | 0.34 |
| ▸ | KDM5C | P41229 | 1/20 | 0.34 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | GLS | O94925 | 2/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | RECQL | P46063 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15994346 | 0.86 | KDM5B (0.35) | KDM4AKDM5CKDM5BCYP2D6CYP3A4 | |
| SCHEMBL16293110 | 0.85 | KDM2B (0.38) | HTR1AGSK3B | |
| SCHEMBL15994518 | 0.82 | KDM5B (0.32) | KDM4AKDM5CKDM5BCYP2D6KCNH2 | |
| SCHEMBL15636644 | 0.72 | KDM5B (0.51) | KDM4AKDM4BKDM5CKDM5B | |
| SCHEMBL15994191 | 0.72 | SIRT2 (0.41) | KDM4AKDM4BKDM5CKDM5B | |
| SCHEMBL15994123 | 0.72 | CYP3A4 (0.31) | KDM4AKDM5CKDM5BCYP2D6CYP3A4 | |
| SCHEMBL18831151 | 0.72 | CYP3A4 (0.31) | KDM4AKDM5CKDM5BCYP2D6CYP3A4 | |
| SCHEMBL16303319 | 0.72 | CYP3A4 (0.31) | KDM4AKDM5CKDM5BCYP2D6CYP3A4 | |
| SCHEMBL19676414 | 0.71 | GLS (0.41) | CYP2D6KCNH2GRIN2BGLSMEN1 | |
| SCHEMBL16293002 | 0.71 | KDM5B (0.43) | KDM4AKDM4BKDM5CKDM5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014131777-A1 | INHIBITORS OF HISTONE DEMETHYLASES | EPITHERAPEUTICS APS (DK) | 2014-09-04 | — | — | WO | disclosed |