Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.59 |
| ▸ | TACR1 | P25103 | 2/20 | 0.55 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.55 |
| ▸ | HTR1A | P08908 | 1/20 | 0.55 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.55 |
| ▸ | HTR1D | P28221 | 1/20 | 0.55 |
| ▸ | HTR1B | P28222 | 1/20 | 0.55 |
| ▸ | HTR2C | P28335 | 1/20 | 0.55 |
| ▸ | HTR1E | P28566 | 1/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.55 |
| ▸ | HTR7 | P34969 | 1/20 | 0.55 |
| ▸ | HTR2B | P41595 | 1/20 | 0.55 |
| ▸ | HTR6 | P50406 | 1/20 | 0.55 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.55 |
| ▸ | AKT1 | P31749 | 11/20 | 0.49 |
| ▸ | AKT2 | P31751 | 2/20 | 0.47 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.47 |
| ▸ | AKT3 | Q9Y243 | 2/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14811516 | 1.00 | HTR2A (0.59) | HTR2ATACR1ADRB1HTR1AADRA2A | |
| SCHEMBL19412146 | 0.84 | HTR2A (0.55) | HTR2ATACR1ADRB1HTR1AADRA2A | |
| SCHEMBL19412147 | 0.84 | HTR2A (0.55) | HTR2ATACR1ADRB1HTR1AADRA2A | |
| SCHEMBL30354011 | 0.84 | HTR2A (0.55) | HTR2ATACR1ADRB1HTR1AADRA2A | |
| SCHEMBL21292958 | 0.80 | HTR2A (0.70) | HTR2ATACR1ADRB1HTR1AADRA2A | |
| SCHEMBL21292957 | 0.80 | HTR2A (0.70) | HTR2ATACR1ADRB1HTR1AADRA2A | |
| Hydrochloric Acid SCHEMBL4632780 | 0.79 | HTR2A (0.68) | HTR2ATACR1ADRB1HTR1AADRA2A | |
| SCHEMBL20430493 | 0.78 | HTR2A (0.71) | HTR2ATACR1ADRB1HTR1AADRA2A | |
| SCHEMBL7902192 | 0.78 | HTR2A (0.50) | HTR2AHTR1AHTR1DHTR1BHTR2C | |
| SCHEMBL20763847 | 0.77 | HTR2A (0.70) | HTR2ATACR1ADRB1HTR1AADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10155259-B2 | FSH receptor antagonists | MERCK SHARP & DOHME B.V. (NL) | 2018-12-18 | — | — | US | disclosed |
| EP-2763986-B1 | FSH RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME (NL) | 2017-06-07 | — | — | EP | disclosed |
| EP-2855431-B1 | FSH RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME (NL) | 2016-07-06 | — | — | EP | disclosed |
| US-20150329545-A1 | FSH RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME B.V. (NL) | 2015-11-19 | — | — | US | disclosed |
| US-9127007-B2 | FSH receptor antagonists | MERCK SHARP & DOHME B.V. (NL) | 2015-09-08 | — | — | US | disclosed |
| US-9044463-B2 | FSH receptor antagonists | MERCK SHARP & DOHME B.V. (NL) | 2015-06-02 | — | — | US | disclosed |
| US-20140350043-A1 | FSH RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME B.V. (NL) | 2014-11-27 | — | — | US | disclosed |
| US-20140256725-A1 | FSH RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME B.V. (NL) | 2014-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140350043-A1 | FSH RECEPTOR ANTAGONISTS | FSHR, GNRHR, LHCGR | HTR2A 1656/4885TACR1 41/4885ADRB1 178/4885 |
| US-20140256725-A1 | FSH RECEPTOR ANTAGONISTS | FSHR, GNRHR, LHCGR | HTR2A 1655/4885TACR1 36/4885ADRB1 178/4885 |
| US-10155259-B2 | FSH receptor antagonists | FSHR, GNRHR, LHCGR | HTR2A 1655/4885TACR1 36/4885ADRB1 178/4885 |
| US-20150329545-A1 | FSH RECEPTOR ANTAGONISTS | FSHR, GNRHR, LHCGR | HTR2A 1655/4885TACR1 36/4885ADRB1 178/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.