Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.63 |
| ▸ | CA1 | P00915 | 1/20 | 0.63 |
| ▸ | CA2 | P00918 | 1/20 | 0.63 |
| ▸ | CA9 | Q16790 | 1/20 | 0.63 |
| ▸ | KDR | P35968 | 16/20 | 0.62 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.58 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.51 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.51 |
| ▸ | FLT3 | P36888 | 4/20 | 0.50 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.50 |
| ▸ | RET | P07949 | 1/20 | 0.50 |
| ▸ | LTK | P29376 | 1/20 | 0.50 |
| ▸ | CDK8 | P49336 | 1/20 | 0.50 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.50 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.50 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.50 |
| ▸ | KIT | P10721 | 3/20 | 0.49 |
| ▸ | TEK | Q02763 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16008176 | 0.88 | CA12 (0.54) | CA12CA1CA2CA9KDR | |
| SCHEMBL4718055 | 0.81 | KDR (0.61) | CA12CA1CA2CA9KDR | |
| SCHEMBL21750852 | 0.80 | CA12 (0.70) | CA12CA1CA2CA9KDR | |
| SCHEMBL4340395 | 0.79 | CA12 (0.69) | CA12CA1CA2CA9KDR | |
| SCHEMBL13541769 | 0.79 | CA12 (0.69) | CA12CA1CA2CA9KDR | |
| SCHEMBL5271094 | 0.79 | KDR (0.69) | CA12CA1CA2CA9KDR | |
| SCHEMBL31504015 | 0.77 | KDM4E (0.62) | CA12CA1CA2CA9KDR | |
| SCHEMBL674031 | 0.77 | CA2 (1.00) | CA12CA1CA2CA9KDR | |
| SCHEMBL16007984 | 0.77 | KDR (1.00) | CA12CA1CA2CA9KDR | |
| SCHEMBL16007986 | 0.77 | KDR (1.00) | CA12CA1CA2CA9KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9321721-B2 | Kinase inhibitors | ALLERGAN, INC. (US) | 2016-04-26 | — | — | US | disclosed |
| US-9321721-B2 | Kinase inhibitors | ALLERGAN, INC. (US) | 2016-04-26 | — | — | US | disclosed |
| US-9321721-B2 | Kinase inhibitors | ALLERGAN, INC. (US) | 2016-04-26 | — | — | US | disclosed |
| WO-2014138452-A1 | KINASE INHIBITORS | ALLERGAN, INC. (US) | 2014-09-12 | — | — | WO | disclosed |
| WO-2014138452-A1 | KINASE INHIBITORS | ALLERGAN, INC. (US) | 2014-09-12 | — | — | WO | disclosed |
| US-20140256819-A1 | KINASE INHIBITORS | ALLERGAN, INC. (US) | 2014-09-11 | — | — | US | disclosed |
| US-20140256819-A1 | KINASE INHIBITORS | ALLERGAN, INC. (US) | 2014-09-11 | — | — | US | disclosed |
| US-20140256819-A1 | KINASE INHIBITORS | ALLERGAN, INC. (US) | 2014-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140256819-A1 | KINASE INHIBITORS | CDK1, MAP3K1, MAPK1 | CA12 4843/4885CA1 4463/4885CA2 2946/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.