Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK3 | O43781 | 4/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.39 |
| ▸ | CDK9 | P50750 | 4/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.39 |
| ▸ | CDK5R1 | Q15078 | 4/20 | 0.39 |
| ▸ | DYRK2 | Q92630 | 4/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 4/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.39 |
| ▸ | CDK2 | P24941 | 3/20 | 0.39 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 3/20 | 0.33 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.31 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | METAP2 | P50579 | 1/20 | 0.30 |
| ▸ | AXL | P30530 | 1/20 | 0.30 |
| ▸ | MERTK | Q12866 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16010240 | 0.74 | MKNK1 (0.35) | — | |
| SCHEMBL16009213 | 0.70 | FYN (0.48) | DYRK3CCNT1CDK9CDK5DYRK1A | |
| SCHEMBL16008823 | 0.65 | FYN (0.45) | DYRK3CCNT1CDK9CDK5DYRK1A | |
| SCHEMBL23932068 | 0.62 | CDK5 (0.65) | DYRK3CCNT1CDK9CDK5DYRK1A | |
| SCHEMBL17968673 | 0.61 | CCNT1 (0.49) | DYRK3CCNT1CDK9CDK5DYRK1A | |
| SCHEMBL2951834 | 0.59 | CCNT1 (0.57) | DYRK3CCNT1CDK9CDK5DYRK1A | |
| SCHEMBL23932223 | 0.59 | CCNT1 (0.50) | DYRK3CCNT1CDK9CDK5DYRK1A | |
| SCHEMBL23932078 | 0.58 | CCNT1 (0.54) | DYRK3CCNT1CDK9CDK5DYRK1A | |
| SCHEMBL16017040 | 0.57 | DYRK1A (0.79) | DYRK3CCNT1CDK9CDK5DYRK1A | |
| SCHEMBL16009453 | 0.57 | DYRK1A (0.79) | DYRK3CCNT1CDK9CDK5DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9370515-B2 | Mixed lineage kinase inhibitors and method of treatments | Califia Bio, Inc. (US) | 2016-06-21 | — | — | US | disclosed |
| US-20140256733-A1 | MIXED LINEAGE KINASE INHIBITORS AND METHOD OF TREATMENTS | Califia Bio, Inc. (US) | 2014-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140256733-A1 | MIXED LINEAGE KINASE INHIBITORS AND METHOD OF TREATMENTS | MAP3K2, MAP3K1, MAP3K20 | DYRK3 514/4885CCNT1 1234/4885CDK9 109/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.