Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | CTSA | P10619 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5206196 | 0.79 | KMT2A (0.48) | KMT2APOLBMAPTKDM4CHDAC3 | |
| SCHEMBL25381974 | 0.78 | EPHB4 (0.50) | KMT2AHDAC3HDAC4HDAC1HDAC7 | |
| Methane SCHEMBL11623540 | 0.78 | KMT2A (0.47) | KMT2APOLBMAPTKDM4CHDAC3 | |
| SCHEMBL26112133 | 0.78 | ACSS2 (0.47) | KMT2APOLBBRD4ADORA3ADORA2A | |
| Ethane SCHEMBL11626038 | 0.76 | KMT2A (0.50) | KMT2APOLBMAPTKDM4CHDAC3 | |
| Propane SCHEMBL11622678 | 0.75 | KMT2A (0.49) | KMT2AKDM4CHDAC3HDAC4HDAC1 | |
| SCHEMBL5650249 | 0.72 | IDO1 (0.42) | POLBPARP1MAPTADORA3ADORA2A | |
| SCHEMBL16045671 | 0.72 | PDK2 (0.58) | KMT2A | |
| SCHEMBL2277762 | 0.70 | KMT2A (0.53) | KMT2APARP1 | |
| SCHEMBL31128114 | 0.70 | KMT2A (0.53) | KMT2APARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970285-B1 | FUSED TETRACYCLIC BROMODOMAIN INHIBITORS | ABBVIE INC (US) | 2019-04-17 | — | — | EP | disclosed |
| US-20190008866-A1 | BROMODOMAIN INHIBITORS | ABBVIE INC (US) | 2019-01-10 | — | — | US | disclosed |
| EP-3089970-B1 | DIHYDROPYRIDINONE AND DIHYDROPYRIDAZINONE DERIVATIVES USEFUL AS BROMODOMAIN INHIBITORS | ABBVIE INC (US) | 2018-10-17 | — | — | EP | disclosed |
| US-10085985-B2 | Bromodomain inhibitors | ABBVIE INC. (US) | 2018-10-02 | — | — | US | disclosed |
| US-20160331749-A1 | BROMODOMAIN INHIBITORS | ABBVIE INC (US) | 2016-11-17 | — | — | US | disclosed |
| EP-3089970-A1 | DIHYDROPYRIDINONE AND DIHYDROPYRIDAZINONE DERIVATIVES USEFUL AS BROMODOMAIN INHIBITORS | AbbVie Inc. (US) | 2016-11-09 | — | — | EP | disclosed |
| CN-105939996-A | Dihydropyridone and dihydropyridazinone derivatives as bromodomain inhibitors | 艾伯维公司 | 2016-09-14 | — | — | CN | disclosed |
| US-9428514-B2 | Bromodomain inhibitors | ABBVIE INC. (US) | 2016-08-30 | — | — | US | disclosed |
| EP-2970285-A1 | FUSED TETRACYCLIC BROMODOMAIN INHIBITORS | AbbVie Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| CN-105189504-A | Fused tetracyclic bromodomain inhibitors | ABBVIE INC | 2015-12-23 | — | — | CN | disclosed |
| WO-2015089075-A1 | DIHYDROPYRIDINONE AND DIHYDROPYRIDAZINONE DERIVATIVES USEFUL AS BROMODOMAIN INHIBITORS | ABBVIE INC. (US) | 2015-06-18 | — | — | WO | disclosed |
| US-20150158873-A1 | BROMODOMAIN INHIBITORS | ABBVIE INC. | 2015-06-11 | — | — | US | disclosed |
| US-20150150884-A1 | BROMODOMAIN INHIBITORS | ABBVIE INC. | 2015-06-04 | — | — | US | disclosed |
| US-8980879-B2 | Bromodomain inhibitors | ABBVIE INC. (US) | 2015-03-17 | — | — | US | disclosed |
| WO-2014164780-A1 | FUSED TETRACYCLIC BROMODOMAIN INHIBITORS | ABBVIE INC. (US) | 2014-10-09 | — | — | WO | disclosed |
| US-20140256710-A1 | BROMODOMAIN INHIBITORS | ABBVIE INC. | 2014-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150150884-A1 | BROMODOMAIN INHIBITORS | BRD4, BRD3, BRD1 | KMT2A 350/4885POLB 910/4885PARP1 98/4885 |
| US-10085985-B2 | Bromodomain inhibitors | BRD4, BRD3, BRD1 | KMT2A 383/4885POLB 840/4885PARP1 87/4885 |
| US-20190008866-A1 | BROMODOMAIN INHIBITORS | BRD4, BRD3, BRD1 | KMT2A 383/4885POLB 840/4885PARP1 87/4885 |
| US-20160331749-A1 | BROMODOMAIN INHIBITORS | BRD4, BRD3, BRD1 | KMT2A 383/4885POLB 840/4885PARP1 87/4885 |
| US-20140256710-A1 | BROMODOMAIN INHIBITORS | BRD4, BRD3, BRD1 | KMT2A 350/4885POLB 910/4885PARP1 98/4885 |
| US-20150158873-A1 | BROMODOMAIN INHIBITORS | BRD4, BRD3, BRD1 | KMT2A 383/4885POLB 840/4885PARP1 87/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.