Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.71 |
| ▸ | NPC1 | O15118 | 2/20 | 0.71 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.56 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.56 |
| ▸ | PPARG | P37231 | 2/20 | 0.56 |
| ▸ | PPARA | Q07869 | 2/20 | 0.56 |
| ▸ | CFTR | P13569 | 4/20 | 0.55 |
| ▸ | GFER | P55789 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | IGF1R | P08069 | 1/20 | 0.51 |
| ▸ | MET | P08581 | 1/20 | 0.51 |
| ▸ | SRC | P12931 | 1/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.50 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.50 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL396865 | 0.93 | CFTR (0.66) | MEN1KMT2ANPC1MAPK14NR1H4 | |
| SCHEMBL1600113 | 0.79 | FLT3 (0.56) | NPC1MAPK14MAPTKDM4EALDH1A1 | |
| SCHEMBL92372 | 0.78 | MEN1 (0.76) | MEN1KMT2ANPC1CFTRGFER | |
| SCHEMBL399067 | 0.78 | MEN1 (0.64) | MEN1KMT2ANPC1CFTRADORA3 | |
| SCHEMBL92355 | 0.78 | KMT2A (0.67) | MEN1KMT2ANPC1CFTRGFER | |
| SCHEMBL7237292 | 0.77 | MEN1 (0.74) | MEN1KMT2ANPC1CFTRGFER | |
| SCHEMBL396908 | 0.77 | MEN1 (0.54) | MEN1KMT2ANPC1CFTRMAPT | |
| SCHEMBL12368183 | 0.76 | MEN1 (0.64) | MEN1KMT2ANPC1MAPK14NR1H4 | |
| SCHEMBL11998126 | 0.76 | CFTR (0.73) | CFTRADORA3ADRB3TBXA2RSLC6A2 | |
| SCHEMBL399216 | 0.75 | MEN1 (0.83) | MEN1KMT2ANPC1CFTRGFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7919617-B2 | Cytokine inhibitors | iTherX Pharmaceuticals Inc. (US) | 2011-04-05 | — | — | US | disclosed |
| US-7897599-B2 | Cytokine inhibitors | iTherX Pharmaceuticals Inc. (US) | 2011-03-01 | — | — | US | disclosed |