Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 6/20 | 0.56 |
| ▸ | CDK2 | P24941 | 2/20 | 0.56 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | RAC1 | P63000 | 1/20 | 0.53 |
| ▸ | EPHB3 | P54753 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.52 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.51 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL951232 | 0.84 | EPHB3 (0.66) | FLT3CDK2KDM4EALDH1A1HPGD | |
| SCHEMBL1600051 | 0.80 | MAPK14 (0.60) | FLT3CDK2MAPK14KDM4ERAC1 | |
| SCHEMBL1600947 | 0.79 | MEN1 (0.71) | MAPK14KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL4519232 | 0.77 | FLT3 (0.57) | FLT3CDK2KDM4EALDH1A1MAPT | |
| SCHEMBL396865 | 0.77 | CFTR (0.66) | MAPK14NPC1L3MBTL1 | |
| SCHEMBL4524085 | 0.76 | FLT3 (0.83) | FLT3CDK2KDM4EALDH1A1MAPT | |
| SCHEMBL903579 | 0.73 | MAPK14 (0.62) | MAPK14KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL954628 | 0.72 | EPHB3 (0.71) | FLT3CDK2KDM4EEPHB3CCNA2 | |
| SCHEMBL7846799 | 0.72 | SMN1; SMN2 (0.60) | FLT3CDK2KDM4EALDH1A1NPC1 | |
| SCHEMBL4555728 | 0.72 | FLT3 (0.55) | FLT3CDK2KDM4EALDH1A1RAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7919617-B2 | Cytokine inhibitors | iTherX Pharmaceuticals Inc. (US) | 2011-04-05 | — | — | US | disclosed |
| US-7897599-B2 | Cytokine inhibitors | iTherX Pharmaceuticals Inc. (US) | 2011-03-01 | — | — | US | disclosed |