Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR3 | Q99500 | 16/20 | 0.67 |
| ▸ | S1PR1 | P21453 | 12/20 | 0.67 |
| ▸ | S1PR2 | O95136 | 11/20 | 0.67 |
| ▸ | S1PR4 | O95977 | 6/20 | 0.67 |
| ▸ | LPAR2 | Q9HBW0 | 5/20 | 0.58 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16010912 | 0.89 | S1PR3 (0.57) | S1PR3S1PR1S1PR2S1PR4LPAR2 | |
| SCHEMBL15795325 | 0.87 | S1PR3 (0.57) | S1PR3S1PR1S1PR2S1PR4LPAR2 | |
| SCHEMBL16010874 | 0.86 | S1PR1 (0.81) | S1PR3S1PR1S1PR2S1PR4LPAR2 | |
| SCHEMBL16010815 | 0.83 | S1PR3 (0.58) | S1PR3S1PR1S1PR2S1PR4LPAR2 | |
| SCHEMBL16011122 | 0.83 | S1PR3 (0.58) | S1PR3S1PR1S1PR2S1PR4LPAR2 | |
| SCHEMBL16011114 | 0.81 | S1PR3 (0.58) | S1PR3S1PR1S1PR2S1PR4LPAR2 | |
| SCHEMBL15794981 | 0.80 | S1PR3 (0.54) | S1PR3S1PR1S1PR2S1PR4LPAR2 | |
| SCHEMBL14195748 | 0.80 | S1PR1 (0.72) | S1PR3S1PR1S1PR2S1PR4LPAR2 | |
| SCHEMBL16026090 | 0.79 | HDAC1 (0.44) | S1PR3S1PR1S1PR2S1PR4S1PR5 | |
| SCHEMBL15795577 | 0.79 | S1PR3 (0.48) | S1PR3S1PR1S1PR2S1PR4LPAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014138075-A1 | PHOSPHONIC ACID COMPOUNDS AS SPHINGOSINE-1-PHOSPHATE RECEPTOR MODULATORS | ALLERGAN, INC. (US) | 2014-09-12 | — | — | WO | claimed |
| US-20140256945-A1 | PHOSPHONIC ACID COMPOUNDS AS SPHINGOSINE-1-PHOSPHATE RECEPTOR MODULATORS | ALLERGAN, INC. (US) | 2014-09-11 | — | — | US | claimed |
| WO-2014138075-A1 | PHOSPHONIC ACID COMPOUNDS AS SPHINGOSINE-1-PHOSPHATE RECEPTOR MODULATORS | ALLERGAN, INC. (US) | 2014-09-12 | — | — | WO | disclosed |
| US-20140256945-A1 | PHOSPHONIC ACID COMPOUNDS AS SPHINGOSINE-1-PHOSPHATE RECEPTOR MODULATORS | ALLERGAN, INC. (US) | 2014-09-11 | — | — | US | disclosed |
| US-20140256945-A1 | PHOSPHONIC ACID COMPOUNDS AS SPHINGOSINE-1-PHOSPHATE RECEPTOR MODULATORS | ALLERGAN, INC. (US) | 2014-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140256945-A1 | PHOSPHONIC ACID COMPOUNDS AS SPHINGOSINE-1-PHOSPHATE RECEPTOR MODULATORS | S1PR1, S1PR2, S1PR5 | S1PR3 4/4885S1PR1 1/4885S1PR2 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.