Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | PTK6 | Q13882 | 6/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 5/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.43 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.43 |
| ▸ | PLG | P00747 | 1/20 | 0.42 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.39 |
| ▸ | PRKCI | P41743 | 1/20 | 0.39 |
| ▸ | PLAU | P00749 | 2/20 | 0.38 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.38 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.38 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.38 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.38 |
| ▸ | HTR3B | O95264 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16011816 | 0.81 | GRIN2D (0.43) | MAPK14PTK6ALKERBB2AURKA | |
| SCHEMBL16024047 | 0.80 | ERBB2 (0.61) | MAPK14PTK6ALKERBB2AURKA | |
| SCHEMBL16011993 | 0.80 | MAPK14 (0.48) | MAPK14PTK6ALKERBB2AURKA | |
| SCHEMBL16011996 | 0.78 | PTK6 (0.47) | MAPK14PTK6ALKERBB2AURKA | |
| SCHEMBL17471213 | 0.78 | PTK6 (0.49) | MAPK14PTK6ALKERBB2AURKA | |
| SCHEMBL16257469 | 0.77 | LRRK2 (0.53) | MAPK14PTK6ALKERBB2AURKA | |
| SCHEMBL16011810 | 0.77 | EGFR (0.47) | MAPK14PTK6ALKERBB2AURKA | |
| SCHEMBL16011815 | 0.76 | F3 (0.42) | MAPK14PTK6ALKERBB2AURKA | |
| SCHEMBL23967926 | 0.75 | PTK6 (0.49) | MAPK14PTK6ALKERBB2AURKA | |
| SCHEMBL674288 | 0.75 | MAPK14 (0.60) | MAPK14PTK6ALKERBB2ACVR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2964225-A1 | CaMKII INHIBITORS AND USES THEREOF | Allosteros Therapeutics Inc. (US) | 2016-01-13 | — | — | EP | disclosed |
| WO-2014138212-A1 | CaMKII INHIBITORS AND USES THEREOF | ALLOSTEROS THERAPEUTICS, INC. (US) | 2014-09-12 | — | — | WO | disclosed |