Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Soman. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSA | P10619 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | LAP3 | P28838 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Soman SCHEMBL7874079 | 0.96 | CTSA (0.36) | CTSAACHELAP3 | |
| Soman SCHEMBL3796733 | 0.93 | CTSA (0.40) | CTSAACHE | |
| Soman SCHEMBL59654 | 0.93 | CTSA (0.40) | CTSAACHE | |
| Soman SCHEMBL16218373 | 0.93 | CTSA (0.40) | CTSAACHE | |
| Soman SCHEMBL17780216 | 0.92 | CTSA (0.33) | CTSAACHE | |
| Soman SCHEMBL30121116 | 0.91 | CTSA (0.39) | CTSAACHE | |
| Soman SCHEMBL30565576 | 0.88 | CTSA (0.33) | CTSAACHE | |
| Soman SCHEMBL2592006 | 0.87 | CTSA (0.46) | CTSAACHE | |
| Soman SCHEMBL28537981 | 0.84 | TDP1 (0.37) | CTSAACHE | |
| Soman SCHEMBL29801574 | 0.84 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150004716-A1 | Detection of Exposure to Chemical Warfare Nerve Agents with Lateral Flow Assays | RAPID PATHOGEN SCREENING, INC. (US) | 2015-01-01 | — | — | US | disclosed |
| WO-2014137862-A2 | DETECTION OF EXPOSURE TO CHEMICAL WARFARE NERVE AGENTS WITH LATERAL FLOW ASSAYS | RAPID PATHOGEN SCREENING, INC. (US) | 2014-09-12 | — | — | WO | disclosed |